ZFIN is now using GRCz12tu for Genomic Data
Gene
braf
- ID
- ZDB-GENE-040805-1
- Name
- B-Raf proto-oncogene, serine/threonine kinase
- Symbol
- braf Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to be active in cytosol; mitochondrion; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu590 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cardiofaciocutaneous syndrome 1 | Alliance | Cardiofaciocutaneous syndrome | 115150 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| lung cancer | Alliance | Adenocarcinoma of lung, somatic | 211980 |
| lung cancer | Alliance | Nonsmall cell lung cancer, somatic | 211980 |
| Noonan syndrome 7 | Alliance | Noonan syndrome 7 | 613706 |
| Noonan syndrome with multiple lentigines 3 | Alliance | LEOPARD syndrome 3 | 613707 |
| Melanoma, malignant, somatic | 155600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR003116 | Raf-like Ras-binding |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Raf-like Ras-binding | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DFX5 | InterPro | 777 | |||||||||||
| UniProtKB:Q1LYG2 | InterPro | 817 | |||||||||||
| UniProtKB:A0A8M9Q0C0 | InterPro | 575 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers