Gene
sdhc
- ID
- ZDB-GENE-040801-26
- Name
- succinate dehydrogenase complex, subunit C, integral membrane protein
- Symbol
- sdhc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143291 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carney-Stratakis syndrome | Alliance | Paraganglioma and gastric stromal sarcoma | 606864 |
| gastrointestinal stromal tumor | Alliance | Gastrointestinal stromal tumor | 606764 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 3 | 605373 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018495 | Succinate dehydrogenase, cytochrome b subunit, conserved site |
| Family | IPR000701 | Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit |
| Family | IPR014314 | Succinate dehydrogenase, cytochrome b556 subunit |
| Homologous_superfamily | IPR034804 | Fumarate reductase/succinate dehydrogenase, transmembrane subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fumarate reductase/succinate dehydrogenase, transmembrane subunit | Succinate dehydrogenase, cytochrome b556 subunit | Succinate dehydrogenase, cytochrome b subunit, conserved site | Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit |
|---|---|---|---|---|---|---|
| UniProtKB:B0S5Q2 | InterPro | 169 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-35B8 | ZFIN Curated Data | |
| Encodes | EST | fa91d04 | ||
| Encodes | EST | IMAGE:7143291 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100898 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003523 (1) | 775 nt | ||
| Genomic | GenBank:AL935192 (1) | 192649 nt | ||
| Polypeptide | UniProtKB:B0S5Q2 (1) | 169 aa |
- Ulhaq, Z.S., Tse, W.K.F. (2024) Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1870(4):167128
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Xu, S.S., Li, Y., Wang, H.P., Chen, W.B., Wang, Y.Q., Song, Z.W., Liu, H., Zhong, S., Sun, Y.H. (2023) Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Zoological research. 44:63-77
- Di, S., Wang, Z., Cang, T., Xie, Y., Zhao, H., Qi, P., Wang, X., Xu, H., Wang, X. (2021) Enantioselective toxicity and mechanism of chiral fungicide penflufen based on experiments and computational chemistry. Ecotoxicology and environmental safety. 222:112534
- Huang, X., Zhao, X., Zhu, K., Ding, S., Shao, B. (2020) Sodium dehydroacetate exposure decreases locomotor persistence and hypoxia tolerance in zebrafish. Environmental research. 195:110276
- Pereira, A.G., Jaramillo, M.L., Remor, A.P., Latini, A., Davico, C.E., da Silva, M.L., Müller, Y.M.R., Ammar, D., Nazari, E.M. (2018) Low-concentration exposure to glyphosate-based herbicide modulates the complexes of the mitochondrial respiratory chain and induces mitochondrial hyperpolarization in the Danio rerio brain. Chemosphere. 209:353-362
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Tallafuss, A., Hale, L.A., Yan, Y.L., Dudley, L., Eisen, J.S., and Postlethwait, J.H. (2006) Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Gene expression patterns : GEP. 6(5):556-565
- van der Ven, K., De Wit, M., Keil, D., Moens, L., Van Leemput, K., Naudts, B., and De Coen, W. (2005) Development and application of a brain-specific cDNA microarray for effect evaluation of neuro-active pharmaceuticals in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 141(4):408-417
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