Gene
c1qb
- ID
- ZDB-GENE-040801-223
- Name
- complement component 1, q subcomponent, B chain
- Symbol
- c1qb Nomenclature History
- Previous Names
-
- zgc:91810
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Acts upstream of or within complement activation, classical pathway. Predicted to be located in extracellular region. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human C1QB (complement C1q B chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91810 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| C1q deficiency 2 | 620321 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Collagen/C1q domain-containing | Collagen triple helix repeat | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DBS9 | InterPro | 242 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-69C1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91810 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173823 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191163 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003482 (1) | 930 nt | ||
| Genomic | GenBank:BX510940 (1) | 172605 nt | ||
| Polypeptide | UniProtKB:Q6DBS9 (1) | 242 aa |
- Bruckner, J.J., Stednitz, S.J., Grice, M.Z., Zaidan, D., Massaquoi, M.S., Larsch, J., Tallafuss, A., Guillemin, K., Washbourne, P., Eisen, J.S. (2022) The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons. PLoS Biology. 20:e3001838
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
- Mitchell, D.M., Sun, C., Hunter, S.S., New, D.D., Stenkamp, D.L. (2019) Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768
- Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R.L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D.Y.R., Levkowitz, G. (2018) Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces. Developmental Cell. 47(6):711-726.e5
- Earley, A.M., Graves, C.L., Shiau, C.E. (2018) Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish. Cell Reports. 25:424-436
- Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
- Oosterhof, N., Holtman, I.R., Kuil, L.E., van der Linde, H.C., Boddeke, E.W., Eggen, B.J., van Ham, T.J. (2017) Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 65(1):138-149
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Tran, M.T.N., Hamada, M., Jeon, H., Shiraishi, R., Asano, K., Hattori, M., Nakamura, M., Imamura, Y., Tsunakawa, Y., Fujii, R., Usui, T., Kulathunga, K., Andrea, C.S., Koshida, R., Kamei, R., Matsunaga, Y., Kobayashi, M., Oishi, H., Kudo, T., Takahashi, S. (2017) MafB is a critical regulator of complement component C1q. Nature communications. 8:1700
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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