ZFIN is now using GRCz12tu for Genomic Data
Gene
ndufa7
- ID
- ZDB-GENE-040801-169
- Name
- NADH:ubiquinone oxidoreductase subunit A7
- Symbol
- ndufa7 Nomenclature History
- Previous Names
-
- zgc:92850
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within heart development and regulation of calcineurin-mediated signaling. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; eye; immature eye; midbrain; and pectoral fin musculature. Used to study hypertrophic cardiomyopathy. Orthologous to human NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92850 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Shi et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hypertrophic cardiomyopathy | twu34Tg + MO1-ndufa7 | standard conditions | Shi et al., 2020 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR009947 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 |
|---|---|---|---|
| UniProtKB:Q6DGM9 | InterPro | 104 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndufa7-201
(1)
|
Ensembl | 482 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-104H9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92850 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191619 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003436 (1) | 559 nt | ||
| Genomic | GenBank:BX548250 (1) | 165603 nt | ||
| Polypeptide | UniProtKB:Q6DGM9 (1) | 104 aa |
- Ganguly, A., Padhan, D.K., Sengupta, A., Chakraborty, P., Sen, M. (2023) CCN6 influences transcription and controls mitochondrial mass and muscle organization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22815e22815
- Shi, X., Zhang, Y., Chen, R., Gong, Y., Zhang, M., Guan, R., Rotstein, O.D., Liu, X., Wen, X.Y. (2020) ndufa7 plays a critical role in cardiac hypertrophy. Journal of Cellular and Molecular Medicine. 24(22):13151-13162
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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