Gene
rcan1a
- ID
- ZDB-GENE-040801-135
- Name
- regulator of calcineurin 1a
- Symbol
- rcan1a Nomenclature History
- Previous Names
-
- zgc:100963 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Acts upstream of or within sprouting angiogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; cardiac ventricle; heart; heart tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of calcineurin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6905699 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Alghanem et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9505 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcipressin | Calcipressin-1, RNA recognition motif | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BFA6 | InterPro | 198 | ||||
| UniProtKB:Q6DC33 | InterPro | 210 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rcan1a-201
(1)
|
Ensembl | 2,773 nt | ||
| mRNA |
rcan1a-202
(1)
|
Ensembl | 814 nt | ||
| ncRNA |
rcan1a-003
(1)
|
Ensembl | 781 nt | ||
| ncRNA |
rcan1a-004
(1)
|
Ensembl | 1,019 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-246M4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-67C22 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6905699 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100963 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003616 (1) | 1815 nt | ||
| Genomic | GenBank:BX855621 (1) | 178447 nt | ||
| Polypeptide | UniProtKB:Q6DC33 (1) | 210 aa |
- Vacca, F., Gomes, A.S., Murashita, K., Cinquetti, R., Roseti, C., Barca, A., Rønnestad, I., Verri, T., Bossi, E. (2022) Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters. The Journal of physiology. 600(10):2377-2400
- Cho, H.J., Lee, J.G., Kim, J.H., Kim, S.Y., Huh, Y.H., Kim, H.J., Lee, K.S., Yu, K., Lee, J.S. (2019) Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish. Disease models & mechanisms. 12(5):
- Burkhard, S.B., Bakkers, J. (2018) Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. eLIFE. 7
- Alghanem, A.F., Wilkinson, E.L., Emmett, M.S., Aljasir, M.A., Holmes, K., Rothermel, B.A., Simms, V.A., Heath, V.L., Cross, M.J. (2017) RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 20(3):341-358
- Chen, Q., Li, C., Gong, Z., Chan, E.C., Snyder, S.A., Lam, S.H. (2017) Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 172:429-439
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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