Gene
trip4
- ID
- ZDB-GENE-040724-92
- Name
- thyroid hormone receptor interactor 4
- Symbol
- trip4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including myotome development; neuromuscular junction development; and thigmotaxis. Predicted to be located in centrosome and cytosol. Predicted to be part of RQC-trigger complex. Predicted to be active in nucleus. Is expressed in cardiac muscle; head; and trunk. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143009 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Knierim et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la026157Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la026158Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la026159Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la026160Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa13764 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa34195 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa41030 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-trip4 | N/A | Knierim et al., 2016 |
MO2-trip4 | N/A | Knierim et al., 2016 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Activating signal cointegrator 1-like | ASCH domain | PUA-like superfamily | TRIP4/RQT4, C2HC5-type zinc finger |
---|---|---|---|---|---|---|
UniProtKB:A0A0R4IR18 | InterPro | 564 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA | ottdart00000002240 (1) | Havana | 1,574 nt | ||
mRNA |
trip4-201
(1)
|
Ensembl | 1,946 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-39A12 | ZFIN Curated Data | |
Contained in | BAC | DKEY-123M8 | ZFIN Curated Data | |
Contained in | BAC | DKEY-173L11 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-221I3 | ||
Encodes | EST | IMAGE:7143009 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:153348 | ZFIN Curated Data |
1 - 6 of 6
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077575 (1) | 1946 nt | ||
Genomic | GenBank:BX649246 (2) | 175267 nt | ||
Polypeptide | UniProtKB:A0A0R4IR18 (1) | 564 aa |
- Gordon, P.M., Hamid, F., Makeyev, E.V., Houart, C. (2021) A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons. Nature communications. 12:1918
- Knierim, E., Hirata, H., Wolf, N.I., Morales-Gonzalez, S., Schottmann, G., Tanaka, Y., Rudnik-Schöneborn, S., Orgeur, M., Zerres, K., Vogt, S., van Riesen, A., Gill, E., Seifert, F., Zwirner, A., Kirschner, J., Goebel, H.H., Hübner, C., Stricker, S., Meierhofer, D., Stenzel, W., Schuelke, M. (2016) Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. American journal of human genetics. 98(3):473-89
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 5 of 5
Show