Gene

lama4

ID
ZDB-GENE-040724-213
Name
laminin, alpha 4
Symbol
lama4 Nomenclature History
Previous Names
  • si:busm1-189a20.2
  • si:dkey-119m7.3
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to enable signaling receptor binding activity. Involved in several processes, including basement membrane assembly; cell migration; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including endothelial cell development; muscle attachment; and notochord development. Predicted to be part of laminin complex. Is expressed in several structures, including cardiovascular system; head; mesoderm; pectoral fin; and trunk musculature. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lama4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1JJ Alliance Cardiomyopathy, dilated, 1JJ 615235
Associated With lama4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR009254 Laminin alpha, domain I
Domain IPR010307 Laminin domain II
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like domain Laminin alpha, domain I Laminin domain II Laminin G domain
UniProtKB:B3DK46 1871
UniProtKB:Q2TJF5 1871
UniProtKB:F1QYU0 1871
UniProtKB:Q5SNU9 1023
UniProtKB:Q5SNV0 148
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations