Gene
tgfa
- ID
- ZDB-GENE-040724-208
- Name
- transforming growth factor, alpha
- Symbol
- tgfa Nomenclature History
- Previous Names
-
- si:ch211-10e8.7
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables molecular sequestering activity. Involved in regulation of circadian sleep/wake cycle, sleep. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in brain; diencephalon; midbrain; retina; and third ventricle. Human ortholog(s) of this gene implicated in gastroenteritis and pancreatic cancer. Orthologous to human TGFA (transforming growth factor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tgfa | Zebrafish Nomenclature Committee | |
| TALEN1-tgfa | (4) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain |
|---|---|---|---|
| UniProtKB:A0A8M3B0K7 | InterPro | 222 | |
| UniProtKB:A0A8M3BAH4 | InterPro | 207 | |
| UniProtKB:Q7T011 | InterPro | 191 | |
| UniProtKB:A0A8M3ATI5 | InterPro | 210 | |
| UniProtKB:A0A8M2BDJ4 | InterPro | 203 |
1 - 5 of 6 Show all
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:tgfa) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10E8 | ||
| Contained in | BAC | CH211-13J1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144052 (1) | 576 nt | ||
| Genomic | GenBank:CR293534 (1) | 109426 nt | ||
| Polypeptide | UniProtKB:A0A8M3B0K7 (1) | 222 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | TGFA | 2 | Amino acid sequence comparison (1) |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Biswas, S., Ghosh, S., Samanta, A., Das, S., Mukherjee, U., Maitra, S. (2020) Bisphenol A impairs reproductive fitness in zebrafish ovary: Potential involvement of oxidative/nitrosative stress, inflammatory and apoptotic mediators. Environmental pollution (Barking, Essex : 1987). 267:115692
- Luo, J., Liu, P., Lu, C., Bian, W., Su, D., Zhu, C., Xie, S., Pan, Y., Li, N., Cui, W., Pei, D.S., Yang, X. (2020) Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish. Brain : a journal of neurology. 144(2):615-635
- Casadei, E., Tacchi, L., Lickwar, C.R., Espenschied, S.T., Davison, J.M., Muñoz, P., Rawls, J.F., Salinas, I. (2019) Commensal bacteria regulate gene expression and differentiation in vertebrate olfactory systems through transcription factor REST. Chemical senses. 44(8):615-630
- Lee, D.A., Liu, J., Hong, Y., Lane, J.M., Hill, A.J., Hou, S.L., Wang, H., Oikonomou, G., Pham, U., Engle, J., Saxena, R., Prober, D.A. (2019) Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling. Science advances. 5:eaax4249
- Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150
- Chen, S., Reichert, S., Singh, C., Oikonomou, G., Rihel, J., Prober, D.A. (2017) Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 95(1):153-168.e6
- Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. 296:31-41
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