Gene

ift74

ID
ZDB-GENE-040718-81
Name
intraflagellar transport 74
Symbol
ift74 Nomenclature History
Previous Names
  • zgc:92052
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable beta-tubulin binding activity. Acts upstream of or within several processes, including opsin transport; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Predicted to be part of intraciliary transport particle B. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Orthologous to human IFT74 (intraflagellar transport 74).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zhu et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ift74 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bardet-Biedl syndrome 22 Alliance Bardet-Biedl syndrome 22 617119
spermatogenic failure 58 Alliance Spermatogenic failure 58 619585
Joubert syndrome 40 619582
1 - 3 of 3
Associated With ift74 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR029602 Intraflagellar transport protein 74
1 - 1 of 1
Domain Details Per Protein
Protein Additional Resources Length Intraflagellar transport protein 74
UniProtKB:A0A8M9PXA7 InterPro 583
UniProtKB:Q6DHU7 InterPro 486
UniProtKB:A0A8M9Q8D0 InterPro 603
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ift74-201 (1) Ensembl 1,752 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations