Gene
fthl27
- ID
- ZDB-GENE-040718-72
- Name
- ferritin, heavy polypeptide-like 27
- Symbol
- fthl27 Nomenclature History
- Previous Names
-
- cb141 (1)
- fj01a11
- fj24b11
- sb:cb141
- wu:fj01a11
- wu:fj24b11
- zgc:92066
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to act upstream of or within intracellular iron ion homeostasis and iron ion transport. Predicted to be active in cytoplasm. Is expressed in several structures, including Kupffer's vesicle; hypochord; mucus secreting cell; segmental plate; and sensory system. Orthologous to human FTMT (ferritin mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb141 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la015170Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la024112Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028898Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa33211 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Ferritin | Ferritin, conserved site | Ferritin/DPS domain | Ferritin-like | Ferritin-like diiron domain | Ferritin-like superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6DHT8 | InterPro | 174 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
zgc:92066-201
(1)
|
Ensembl | 1,086 nt | ||
ncRNA |
zgc:92066-002
(1)
|
Ensembl | 811 nt | ||
ncRNA |
zgc:92066-003
(1)
|
Ensembl | 732 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-237N7 | ZFIN Curated Data | |
Encodes | EST | cb141 | Thisse et al., 2001 | |
Encodes | EST | fj01a11 | ||
Encodes | EST | fj24b11 | ||
Encodes | cDNA | MGC:92066 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001002378 (1) | 916 nt | ||
Genomic | GenBank:BX511080 (1) | 115272 nt | ||
Polypeptide | UniProtKB:Q6DHT8 (1) | 174 aa |
No data available
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Zhang, A.N., Huang, C., Yan, L., Liu, X., Wang, F., Zhang, Z., Li, L., Zhang, C., Zhang, Q. (2023) Metabolic regulation and antihyperglycemic properties of diet-derived PGG through transcriptomic and metabolomic profiling. Food & function. 14(12):5620-5630
- Xi, J., Zhang, Z., Wang, Z., Wu, Q., He, Y., Xu, Y., Ding, Z., Zhao, H., Da, H., Zhang, F., Zhao, H., Fang, J. (2022) Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free radical biology & medicine. 190:202-215
- Fuse, Y., Nakajima, H., Nakajima-Takagi, Y., Nakajima, O., Kobayashi, M. (2015) Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes to cells : devoted to molecular & cellular mechanisms. 20(7):590-600
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
- Xiong, X.P., Dong, C.F., Xu, X., Weng, S.P., Liu, Z.Y., and He, J.G. (2011) Proteomic Analysis of Zebrafish (Danio rerio) Infected with Infectious Spleen and Kidney Necrosis Virus. Developmental and comparative immunology. 35(4):431-440
- Liu, H., Takano, T., Peatman, E., Abernathy, J., Wang, S., Sha, Z., Kucuktas, H., Xu, D.H., Klesius, P., and Liu, Z. (2010) Molecular characterization and gene expression of the channel catfish ferritin H subunit after bacterial infection and iron treatment. Journal of experimental zoology. Part A, Ecological genetics and physiology. 313(6):359-368
- Toro, S., Wegner, J., Muller, M., Westerfield, M., and Varga, Z.M. (2009) Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Gene expression patterns : GEP. 9(4):200-208
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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