Gene

rspo1

ID

ZDB-GENE-040718-44

Name

R-spondin 1

Symbol

rspo1 Nomenclature History

Previous Names

cb1071 (1)
fj81e05
wu:fj81e05
zgc:92153 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have heparin binding activity. Involved in angiogenesis; hematopoietic stem cell differentiation; and vascular endothelial growth factor receptor signaling pathway. Localizes to Golgi apparatus and cytosol. Is expressed in several structures, including nervous system; regenerating fin; reproductive system; steroid hormone secreting cell; and tail bud. Orthologous to human RSPO1 (R-spondin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb1071 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rspo1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Palmoplantar hyperkeratosis and true hermaphroditism	610644
		Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal	610644

Associated With rspo1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR043601	R-spondin, Fu-CRD domain
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR006212	Furin-like repeat