Gene
bcat2
- ID
- ZDB-GENE-040718-425
- Name
- branched chain amino-acid transaminase 2, mitochondrial
- Symbol
- bcat2 Nomenclature History
- Previous Names
-
- fb37h12
- wu:fb37h12
- zgc:91919
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable branched-chain-amino-acid transaminase activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process; branched-chain amino acid biosynthetic process; and lipid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in liver and muscle. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to human BCAT2 (branched chain amino acid transaminase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16687 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20027 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33189 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33190 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypervalinemia and hyperleucine-isoleucinemia | Alliance | Hypervalinemia and hyperleucine-isoleucinemia | 618850 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018300 | Aminotransferase, class IV, conserved site |
| Family | IPR001544 | Aminotransferase class IV |
| Family | IPR005786 | Branched-chain amino acid aminotransferase II |
| Family | IPR033939 | Branched-chain aminotransferase |
| Homologous_superfamily | IPR036038 | Aminotransferase-like, PLP-dependent enzymes |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminotransferase class IV | Aminotransferase, class IV, conserved site | Aminotransferase-like, PLP-dependent enzymes | Branched-chain amino acid aminotransferase II | Branched-chain-amino-acid aminotransferase-like, C-terminal | Branched-chain-amino-acid aminotransferase-like, N-terminal | Branched-chain aminotransferase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QCQ6 | InterPro | 406 | |||||||
| UniProtKB:E9QFU8 | InterPro | 391 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-197M10 | ZFIN Curated Data | |
| Encodes | EST | fb37h12 | ||
| Encodes | cDNA | MGC:91919 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192970 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002676 (1) | 3447 nt | ||
| Genomic | GenBank:CR384107 (1) | 51533 nt | ||
| Polypeptide | UniProtKB:E9QCQ6 (1) | 406 aa |
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Wang, J.G., Zhao, S.H., Qian, Y.C., Qian, Y.F., Liu, Y.C., Qiao, F., Luo, Y., Zhang, M.L., Du, Z.Y. (2022) The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism. The British journal of nutrition. 130(4):588-603
- Li, L.Y., Li, J.M., Ning, L.J., Lu, D.L., Luo, Y., Ma, Q., Limbu, S.M., Li, D.L., Chen, L.Q., Lodhi, I.J., Degrace, P., Zhang, M.L., Du, Z.Y. (2020) Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish. The Journal of nutrition. 150(9):2322-2335
- Li, L.Y., Lv, H.B., Jiang, Z.Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2020) Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. The Journal of physiology. 598(20):4537-4553
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hugo, S.E., Cruz-Garcia, L., Karanth, S., Anderson, R.M., Stainier, D.Y., and Schlegel, A. (2012) A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes & Development. 26(3):282-93
- Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
- Li, Q., Ritter, D., Yang, N., Dong, Z., Li, H., Chuang, J.H., and Guo, S. (2010) A systematic approach to identify functional motifs within vertebrate developmental enhancers. Developmental Biology. 337(2):484-495
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
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