ZFIN is now using GRCz12tu for Genomic Data
Gene
ada
- ID
- ZDB-GENE-040718-393
- Name
- adenosine deaminase
- Symbol
- ada Nomenclature History
- Previous Names
-
- ada1 (1)
- zgc:92028
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables adenosine deaminase activity. Predicted to be involved in several processes, including hypoxanthine salvage; negative regulation of adenosine receptor signaling pathway; and purine ribonucleoside metabolic process. Predicted to act upstream of or within nucleotide metabolic process and purine ribonucleoside monophosphate biosynthetic process. Predicted to be located in several cellular components, including anchoring junction; cytoplasmic vesicle lumen; and lysosome. Predicted to be active in cytosol and external side of plasma membrane. Is expressed in several structures, including digestive system; gill; heart; kidney; and muscle. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911877 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37719 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ada | N/A | Gessler et al., 2022 |
| MO2-ada | N/A | Gessler et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adenosine deaminase deficiency | Alliance | Adenosine deaminase deficiency, partial | 102700 |
| adenosine deaminase deficiency | Alliance | Severe combined immunodeficiency due to ADA deficiency | 102700 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenosine/adenine deaminase | Adenosine/AMP deaminase active site | Adenosine deaminase | Adenosine deaminase domain | Metal-dependent hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DG22 | InterPro | 359 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51B3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-254E8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6911877 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92028 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002646 (1) | 2340 nt | ||
| Genomic | GenBank:CR678304 (1) | 79195 nt | ||
| Polypeptide | UniProtKB:Q6DG22 (1) | 359 aa |
- Gessler, S., Guthmann, C., Schuler, V., Lilienkamp, M., Walz, G., Yakulov, T.A. (2022) Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling. International Journal of Molecular Sciences. 23(14):
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Cruz, F.F., Pereira, T.C.B., Altenhofen, S., da Costa, K.M., Bogo, M.R., Bonan, C.D., Morrone, F.B. (2019) Characterization of the adenosinergic system in a zebrafish embryo radiotherapy model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 224:108572
- Rico, E.P., Rosemberg, D.B., Berteli, J.F.A., da Silveira Langoni, A., Souto, A.A., Bogo, M.R., Bonan, C.D., Souza, D.O. (2018) Adenosine deaminase activity and gene expression patterns are altered after chronic ethanol exposure in zebrafish brain. Neurotoxicology and teratology. 65:14-18
- Wang, F., Liu, F., Chen, W. (2018) Exposure to triclosan changes the expression of microRNA in male juvenile zebrafish (Danio rerio). Chemosphere. 214:651-658
- Altenhofen, S., Nabinger, D.D., Pereira, T.C.B., Leite, C.E., Bogo, M.R., Bonan, C.D. (2017) Manganese(II) Chloride Alters Nucleotide and Nucleoside Catabolism in Zebrafish (Danio rerio) Adult Brain. Molecular neurobiology. 55(5):3866-3874
- Zimmermann, F.F., Gaspary, K.V., Siebel, A.M., Leite, C.E., Kist, L.W., Bogo, M.R., Bonan, C.D. (2017) Analysis of Extracellular Nucleotide Metabolism in Adult Zebrafish After Embryological Exposure to Valproic Acid. Molecular neurobiology. 54(5):3542-3553
- Capiotti, K.M., Siebel, A.M., Kist, L.W., Bogo, M.R., Bonan, C.D., Da Silva, R.S. (2016) Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio). Purinergic signalling. 12(2):211-20
- Li, Z., Long, Y., Zhong, L., Song, G., Zhang, X., Yuan, L., Cui, Z., Dai, H. (2016) RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. Journal of applied toxicology : JAT. 36(1):94-104
- Zimmermann, F.F., Altenhofen, S., Kist, L.W., Leite, C.E., Bogo, M.R., Cognato, G.P., Bonan, C.D. (2016) Unpredictable Chronic Stress Alters Adenosine Metabolism in Zebrafish Brain. Molecular neurobiology. 53(4):2518-28
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