Gene
gsto1
- ID
- ZDB-GENE-040718-365
- Name
- glutathione S-transferase omega 1
- Symbol
- gsto1 Nomenclature History
- Previous Names
-
- fd58h04
- wu:fd58h04
- zgc:92254
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human GSTO1 (glutathione S-transferase omega 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Family | IPR005442 | Glutathione S-transferase, omega-class |
| Family | IPR040079 | Glutathione transferase family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione S-transferase, omega-class | Glutathione S-transferase Omega/HSP26 | Glutathione S-transferase Omega/Tau-like | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DHK5 | InterPro | 240 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51A16 | ZFIN Curated Data | |
| Encodes | EST | fd58h04 | ||
| Encodes | cDNA | MGC:92254 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002621 (1) | 1444 nt | ||
| Genomic | GenBank:BX530079 (1) | 166397 nt | ||
| Polypeptide | UniProtKB:Q6DHK5 (1) | 240 aa |
- Pang, M.Z., Li, H.X., Dai, X.Q., Wang, X.B., Liu, J.Y., Shen, Y., Xu, X., Zhong, Z.M., Wang, H., Liu, C.F., Wang, F. (2024) Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease. Neuroscience Bulletin. 40(12):1901-1914
- Song, L., Li, M., Feng, C., Sa, R., Hu, X., Wang, J., Yin, X., Qi, C., Dong, W., Yang, J. (2022) Protective effect of curcumin on zebrafish liver under ethanol-induced oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 258:109360
- Tierbach, A., Groh, K.J., Schoenenberger, R., Schirmer, K., Suter, M.J. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: Functionality of the mercapturic acid pathway. Toxicological sciences : an official journal of the Society of Toxicology. 176(2):355-365
- Tierbach, A., Groh, K.J., Schönenberger, R., Schirmer, K., Suter, M.J. (2018) Glutathione S-transferase protein expression in different life stages of zebrafish (Danio rerio). Toxicological sciences : an official journal of the Society of Toxicology. 162(2):702-712
- Abunnaja, M.S., Kurogi, K., Mohammed, Y.I., Sakakibara, Y., Suiko, M., Hassoun, E.A., Liu, M.C. (2017) Identification and characterization of the zebrafish glutathione S-transferase Pi-1. Journal of biochemical and molecular toxicology. 31(10)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Duan, J., Yu, Y., Li, Y., Jing, L., Yang, M., Wang, J., Li, Y., Zhou, X., Miller, M.R., Sun, Z. (2017) Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model.. The Science of the total environment. 586:666-674
- Zhao, X., Lorent, K., Wilkins, B., Marchione, D.M., Gillespie, K., Waisbourd-Zinman, O., So, J., Koo, K.A., Shin, D., Porter, J.R., Wells, R.G., Blair, I., Pack, M. (2016) Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology (Baltimore, Md.). 64(3):894-907
- Glisic, B., Mihaljevic, I., Popovic, M., Zaja, R., Loncar, J., Fent, K., Kovacevic, R., Smital, T. (2015) Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 158C:50-62
- Ho, N.Y., Yang, L., Legradi, J., Armant, O., Takamiya, M., Rastegar, S., and Strähle, U. (2013) Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury. Environmental science & technology. 47(7):3316-25
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