Gene

nr1h4

ID
ZDB-GENE-040718-313
Name
nuclear receptor subfamily 1, group H, member 4
Symbol
nr1h4 Nomenclature History
Previous Names
  • FXRalpha (1)
  • zgc:110190
  • zgc:92742 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits bile acid binding activity and nuclear receptor activity. Involved in regulation of transcription, DNA-templated. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Is expressed in intestinal bulb and liver. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr1h4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
progressive familial intrahepatic cholestasis 5 Alliance Cholestasis, progressive familial intrahepatic, 5 617049
Associated With nr1h4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR044114 Bile acid receptor, ligand binding domain
Family IPR001723 Nuclear hormone receptor
Family IPR001728 Thyroid hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Bile acid receptor, ligand binding domain Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Thyroid hormone receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q568N6 483
UniProtKB:Q6DGW7 483
UniProtKB:A0A2R8QR22 483
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations