Gene
cldn7a
- ID
- ZDB-GENE-040718-29
- Name
- claudin 7a
- Symbol
- cldn7a Nomenclature History
- Previous Names
-
- zgc:92192
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within head development. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including eye; gill; heart; integument; and pleuroperitoneal region. Orthologous to human CLDN7 (claudin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cldn7a | N/A | Carvalho et al., 2014 |
| MO2-cldn7a | N/A | Li et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
| UniProtKB:Q6DHP1 | InterPro | 212 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cldn7a-201
(1)
|
Ensembl | 1,606 nt | ||
| ncRNA |
cldn7a-002
(1)
|
Ensembl | 583 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-112A7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92192 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174372 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002340 (1) | 1592 nt | ||
| Genomic | GenBank:BX470146 (1) | 168554 nt | ||
| Polypeptide | UniProtKB:Q6DHP1 (1) | 212 aa |
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):
- Li, X., Song, G., Zhao, Y., Zhao, F., Liu, C., Liu, D., Li, Q., Cui, Z. (2017) Claudin7b is required for the formation and function of inner ear in zebrafish. Journal of Cellular Physiology. 233(4):3195-3206
- Carvalho, C.M., Vasanth, S., Shinawi, M., Russell, C., Ramocki, M.B., Brown, C.W., Graakjaer, J., Skytte, A.B., Vianna-Morgante, A.M., Krepischi, A.C., Patel, G.S., Immken, L., Aleck, K., Lim, C., Cheung, S.W., Rosenberg, C., Katsanis, N., Lupski, J.R. (2014) Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. American journal of human genetics. 95:565-78
- Baltzegar, D.A., Reading, B.J., Brune, E.S., and Borski, R.J. (2013) Phylogenetic revision of the claudin gene family. Marine genomics. 11:17-26
- Davey, C., Tallafuss, A., and Washbourne, P. (2010) Differential expression of neuroligin genes in the nervous system of zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):703-714
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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