Gene

hax1

ID

ZDB-GENE-040718-26

Name

HCLS1 associated protein X-1

Symbol

hax1 Nomenclature History

Previous Names

zgc:92196

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be involved in negative regulation of apoptotic process. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Is expressed in several structures, including hatching gland; lens; mesoderm; myotome; and solid lens vesicle. Orthologous to human HAX1 (HCLS1 associated protein X-1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7158282 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Doll et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hax1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
severe congenital neutropenia 3	Alliance	Neutropenia, severe congenital 3, autosomal recessive	610738

Associated With hax1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
severe congenital neutropenia	TU + MO1-hax1	standard conditions	Doll et al., 2020
severe congenital neutropenia	i114Tg + MO1-hax1	standard conditions	Doll et al., 2020
severe congenital neutropenia	i114Tg + MO2-hax1	standard conditions	Doll et al., 2020
severe congenital neutropenia	TU + MO2-hax1	standard conditions	Doll et al., 2020
severe congenital neutropenia	TU + MO3-hax1	standard conditions	Doll et al., 2020
severe congenital neutropenia	i114Tg + MO3-hax1	standard conditions	Doll et al., 2020
severe congenital neutropenia	i114Tg + CRISPR1-hax1	standard conditions	Doll et al., 2020