Gene
tyrp1b
- ID
- ZDB-GENE-040718-249
- Name
- tyrosinase-related protein 1b
- Symbol
- tyrp1b Nomenclature History
- Previous Names
-
- tyrp1 (1)
- hm:zeh0659
- oca3
- zgc:100893
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable tyrosinase activity. Acts upstream of or within several processes, including melanosome organization; response to thyroid hormone; and retinal pigment epithelium development. Predicted to be located in melanosome membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; hatching gland; immature eye; melanoblast; and pigment cell. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894514 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tyrp1b | (2) | |
| CRISPR2-tyrp1b | Chen et al., 2021 | |
| CRISPR3-tyrp1b | (2) | |
| CRISPR4-tyrp1b | (2) | |
| CRISPR5-tyrp1b | (2) | |
| CRISPR6-tyrp1b | (2) | |
| CRISPR7-tyrp1b | (2) | |
| MO1-tyrp1b | N/A | Braasch et al., 2009 |
| MO2-tyrp1b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oculocutaneous albinism type III | Alliance | Albinism, oculocutaneous, type III | 203290 |
| [Skin/hair/eye pigmentation, variation in, 11 (Melanesian blond hair)] | 612271 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Di-copper centre-containing domain superfamily | Tyrosinase and Hemocyanin | Tyrosinase copper-binding domain |
|---|---|---|---|---|---|
| UniProtKB:Q6DGE4 | InterPro | 526 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tyrp1b-201
(1)
|
Ensembl | 1,969 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(tyrp1b:PALM-mCherry) |
|
| 1 | (11) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-241E15 | ZFIN Curated Data | |
| Contains | SNP | rs3727528 | ZFIN Curated Data | |
| Contains | SNP | rs3727529 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6894514 | Thisse et al., 2004 | |
| Encodes | EST | zeh0659 | ||
| Encodes | cDNA | MGC:100893 | ZFIN Curated Data | |
| Has Artifact | EST | fm95g09 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002749 (1) | 2005 nt | ||
| Genomic | GenBank:BX323883 (1) | 195250 nt | ||
| Polypeptide | UniProtKB:Q6DGE4 (2) | 526 aa |
- Korzeniwsky, K.G., de Mello, P.L.H., Liang, Y., Feltes, M., Farber, S.A., Parichy, D.M. (2025) Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages. Pigment cell & melanoma research. 38:e70009e70009
- Wusiman, Z., Zhang, A.M., Zhang, S.S., Zhao, P.P., Kang, Y.T., Zhang, Y., Li, Z.J., Huo, S.X. (2025) Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway. Frontiers in pharmacology. 16:15210971521097
- Bian, C., Li, R.H., Ruan, Z.Q., Chen, W.T., Huang, Y., Liu, L.Y., Zhou, H.L., Chong, C.M., Mu, X.D., Shi, Q. (2024) Chromosome-level genome assembly of the glass catfish ( Kryptopterus vitreolus) reveals molecular clues to its transparent phenotype. Zoological research. 45:102710361027-1036
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Frantz, W.T., Iyengar, S., Neiswender, J., Cousineau, A., Maehr, R., Ceol, C.J. (2023) Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. eLIFE. 12:
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870
- Maskin, C.R., Raman, R., Houvras, Y. (2022) PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity. Scientific Reports. 12:5573
- Neuffer, S.J., Beltran-Cardona, D., Jimenez-Perez, K., Clancey, L.F., Brown, A., New, L., Cooper, C.D. (2022) AP-3 complex delta subunit gene, ap3d1, regulates melanogenesis and melanophore survival via autophagy in zebrafish (Danio rerio). Pigment cell & melanoma research. 35(5):495-505
- Weiss, J.M., Hunter, M.V., Cruz, N.M., Baggiolini, A., Tagore, M., Ma, Y., Misale, S., Marasco, M., Simon-Vermot, T., Campbell, N.R., Newell, F., Wilmott, J.S., Johansson, P.A., Thompson, J.F., Long, G.V., Pearson, J.V., Mann, G.J., Scolyer, R.A., Waddell, N., Montal, E.D., Huang, T.H., Jonsson, P., Donoghue, M.T.A., Harris, C.C., Taylor, B.S., Xu, T., Chaligné, R., Shliaha, P.V., Hendrickson, R., Jungbluth, A.A., Lezcano, C., Koche, R., Studer, L., Ariyan, C.E., Solit, D.B., Wolchok, J.D., Merghoub, T., Rosen, N., Hayward, N.K., White, R.M. (2022) Anatomic position determines oncogenic specificity in melanoma. Nature. 604(7905):354-361
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