Gene

tk2

ID
ZDB-GENE-040718-243
Name
thymidine kinase 2
Symbol
tk2 Nomenclature History
Previous Names
  • zgc:100948
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have deoxynucleoside kinase activity. Predicted to be involved in nucleobase-containing compound metabolic process and phosphorylation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Is expressed in exocrine pancreas and pectoral fin. Orthologous to human TK2 (thymidine kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tk2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 Alliance ?Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 617069
mitochondrial DNA depletion syndrome 2 Alliance Mitochondrial DNA depletion syndrome 2 (myopathic type) 609560
Associated With tk2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR031314 Deoxynucleoside kinase domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Deoxynucleoside kinase domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M1N0Z5 268
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations