Gene
otub1b
- ID
- ZDB-GENE-040718-204
- Name
- OTU deubiquitinase, ubiquitin aldehyde binding 1b
- Symbol
- otub1b Nomenclature History
- Previous Names
-
- otub1
- fa19h07
- wu:fa19h07 (1)
- zgc:92839
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity and ubiquitin binding activity. Predicted to act upstream of or within protein deubiquitination and proteolysis. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6902223 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44660 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-otub1b | N/A | (2) |
| MO2-otub1b | N/A | Goncharov et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003323 | OTU domain |
| Family | IPR016615 | Ubiquitin thioesterase Otubain |
| Family | IPR019400 | Peptidase C65, otubain |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
| Homologous_superfamily | IPR042467 | Peptidase C65, otubain, subdomain 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | OTU domain | Papain-like cysteine peptidase superfamily | Peptidase C65, otubain | Peptidase C65, otubain, subdomain 1 | Peptidase C65, otubain, subdomain 2 | Ubiquitin thioesterase Otubain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6P1A9 | InterPro | 266 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
otub1b-201
(1)
|
Ensembl | 1,196 nt | ||
| mRNA |
otub1b-202
(1)
|
Ensembl | 744 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226L4 | ZFIN Curated Data | |
| Encodes | EST | fa19h07 | ||
| Encodes | EST | IMAGE:6902223 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92839 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002500 (1) | 1213 nt | ||
| Genomic | GenBank:BX511061 (1) | 200880 nt | ||
| Polypeptide | UniProtKB:F6P1A9 (1) | 266 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Goncharov, T., Niessen, K., de Almagro, M.C., Izrael-Tomasevic, A., Fedorova, A.V., Varfolomeev, E., Arnott, D., Deshayes, K., Kirkpatrick, D.S., and Vucic, D. (2013) OTUB1 modulates c-IAP1 stability to regulate signalling pathways. The EMBO journal. 32(8):1103-14
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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