Gene
setd7
- ID
- ZDB-GENE-040718-156
- Name
- SET domain containing 7, histone lysine methyltransferase
- Symbol
- setd7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable histone H3 methyltransferase activity and protein-lysine N-methyltransferase activity. Acts upstream of or within heart morphogenesis. Predicted to be active in chromosome and nucleus. Is expressed in heart; heart tube; lens; and somite. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101860 (1 image)
- IMAGE:7152055 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kim et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-setd7 | (2) | |
| CRISPR2-setd7 | (2) | |
| CRISPR3-setd7 | (2) | |
| MO1-setd7 | N/A | Huang et al., 2013 |
| MO2-setd7 | N/A | Kim et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-lysine methyltransferase SETD7, N-terminal | Histone-lysine N-methyltransferase SETD7 | MORN repeat | SETD7, SET domain | SET domain | SET domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BGX6 | InterPro | 256 | ||||||
| UniProtKB:Q6DHG0 | InterPro | 373 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113D11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7152055 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92330 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101860 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002456 (1) | 1972 nt | ||
| Genomic | GenBank:BX005077 (1) | 127560 nt | ||
| Polypeptide | UniProtKB:Q6DHG0 (1) | 373 aa |
- Madera, D., Alonso-Gómez, A., Delgado, M.J., Valenciano, A.I., Alonso-Gómez, Á.L. (2023) Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. International Journal of Molecular Sciences. 25(1):
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Saxena, S., Purushothaman, S., Meghah, V., Bhatti, B., Poruri, A., Meena Lakshmi, M.G., Sarath Babu, N., Murthy, C.L., Mandal, K.K., Kumar, A., Idris, M.M. (2016) Role of Annexin gene and its regulation during zebrafish caudal fin regeneration. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(3):551-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, J.D., Kim, E., Koun, S., Ham, H.J., Rhee, M., Kim, M.J., Huh, T.L. (2015) Proper Activity of Histone H3 Lysine 4 (H3K4) Methyltransferase Is Required for Morphogenesis during Zebrafish Cardiogenesis. Molecules and cells. 38(6):580-6
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Long, Y., Song, G., Yan, J., He, X., Li, Q., and Cui, Z. (2013) Transcriptomic characterization of cold acclimation in larval zebrafish. BMC Genomics. 14(1):612
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