Gene
acp5b
- ID
- ZDB-GENE-040718-151
- Name
- acid phosphatase 5b, tartrate resistant
- Symbol
- acp5b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable acid phosphatase activity; ferric iron binding activity; and ferrous iron binding activity. Acts upstream of or within response to mechanical stimulus. Is expressed in scale. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Spondyloenchondrodysplasia with immune dysregulation | 607944 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Metallo-dependent phosphatase-like | Metallophosphoesterase Purple Acid Phosphatase | Purple acid phosphatase |
|---|---|---|---|---|---|
| UniProtKB:Q6DHF5 | InterPro | 327 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-189O17 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-25A6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92339 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002452 (1) | 1299 nt | ||
| Genomic | GenBank:CR548632 (1) | 178393 nt | ||
| Polypeptide | UniProtKB:Q6DHF5 (1) | 327 aa |
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Yu, L., Li, X., He, M., Wang, Q., Chen, C., Li, F., Li, B., Li, L. (2023) Antioxidant Carboxymethyl Chitosan Carbon Dots with Calcium Doping Achieve Ultra-Low Calcium Concentration for Iron-Induced Osteoporosis Treatment by Effectively Enhancing Calcium Bioavailability in Zebrafish. Antioxidants (Basel, Switzerland). 12(3):
- Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
- Molagoda, I.M.N., Athapaththu, A.M.G.K., Park, E.K., Choi, Y.H., Jeon, Y.J., Kim, G.Y. (2022) Fermented Oyster (Crassostrea gigas) Extract Cures and Prevents Prednisolone-Induced Bone Resorption by Activating Osteoblast Differentiation. Foods (Basel, Switzerland). 11(5):
- Peng, C.H., Lin, W.Y., Li, C.Y., Dharini, K.K., Chang, C.Y., Hong, J.T., Lin, M.D. (2022) Gu Sui Bu (Drynaria fortunei J. Sm.) antagonizes glucocorticoid-induced mineralization reduction in zebrafish larvae by modulating the activity of osteoblasts and osteoclasts. Journal of ethnopharmacology. 297:115565
- Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
- Chaichit, S., Sato, T., Yu, H., Tanaka, Y.K., Ogra, Y., Mizoguchi, T., Itoh, M. (2021) Evaluation of Dexamethasone-Induced Osteoporosis In Vivo Using Zebrafish Scales. Pharmaceuticals (Basel, Switzerland). 14(6):
- Gilbert, M.C., Tetrault, E., Packard, M., Navon, D., Albertson, R.C. (2021) Ciliary rootlet coiled-coil 2 (crocc2) is associated with evolutionary divergence and plasticity of cichlid jaw shape. Molecular Biology and Evolution. 38(8):3078-3092
- Molagoda, I.M.N., Kang, C.H., Lee, M.H., Choi, Y.H., Lee, C.M., Lee, S., Kim, G.Y. (2021) Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis. Biochemical pharmacology. 192:114676
- Liang, S.T., Chen, J.R., Tsai, J.J., Lai, Y.H., Hsiao, C.D. (2019) Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish. International Journal of Molecular Sciences. 20(15)
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