Gene

cpsf1

ID
ZDB-GENE-040709-2
Name
cleavage and polyadenylation specific factor 1
Symbol
cpsf1 Nomenclature History
Previous Names
  • wu:fb24c01
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have NAD+ ADP-ribosyltransferase activity and RNA binding activity. Involved in definitive hemopoiesis; mRNA polyadenylation; and retinal ganglion cell axon guidance. Predicted to localize to mRNA cleavage and polyadenylation specificity factor complex. Human ortholog(s) of this gene implicated in myopia. Is expressed in brain; gut; head; and pectoral fin. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cpsf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Myopia 27 618827
Associated With cpsf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004871 Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Domain IPR018846 Cleavage/polyadenylation specificity factor, A subunit, N-terminal
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Domain Details Per Protein
Protein Length Cleavage/polyadenylation specificity factor, A subunit, C-terminal Cleavage/polyadenylation specificity factor, A subunit, N-terminal WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6DRG0 1105
UniProtKB:A0A0R4IH63 400
UniProtKB:A0A0R4IC37 1451
UniProtKB:Q5EB13 416
UniProtKB:A4IGB2 348
UniProtKB:F6NXE7 1448
UniProtKB:A8WFR1 400
UniProtKB:Q6DRG2 312
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations