Gene

cpsf1

ID

ZDB-GENE-040709-2

Name

cleavage and polyadenylation specific factor 1

Symbol

cpsf1 Nomenclature History

Previous Names

wu:fb24c01

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have NAD+ ADP-ribosyltransferase activity and RNA binding activity. Involved in definitive hemopoiesis; mRNA polyadenylation; and retinal ganglion cell axon guidance. Predicted to localize to mRNA cleavage and polyadenylation specificity factor complex. Human ortholog(s) of this gene implicated in myopia. Is expressed in brain; gut; head; and pectoral fin. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6894052 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpsf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myopia 27	618827

Associated With cpsf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Domain	IPR018846	Cleavage/polyadenylation specificity factor, A subunit, N-terminal
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily