Gene
cpa4
- ID
- ZDB-GENE-040704-61
- Name
- carboxypeptidase A4
- Symbol
- cpa4 Nomenclature History
- Previous Names
-
- wu:fb66g10
- zgc:91794
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in pancreas and somite. Orthologous to several human genes including CPA2 (carboxypeptidase A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91794 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24633 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cpa4 | (2) | |
| CRISPR2-cpa4 | Lu et al., 2023 | |
| CRISPR3-cpa4 | Lu et al., 2023 | |
| CRISPR4-cpa4 | Lu et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Carboxypeptidase A, carboxypeptidase domain | Carboxypeptidase, activation peptide | Metallocarboxypeptidase-like, propeptide | Peptidase M14, carboxypeptidase A |
|---|---|---|---|---|---|---|
| UniProtKB:Q6GMH9 | InterPro | 417 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266K8 | ZFIN Curated Data | |
| Encodes | EST | fb66g10 | ||
| Encodes | cDNA | MGC:91794 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191184 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002217 (1) | 1480 nt | ||
| Genomic | GenBank:CR376785 (2) | 173989 nt | ||
| Polypeptide | UniProtKB:Q6GMH9 (1) | 417 aa |
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Akula, S., Hellman, L., Avilés, F.X., Wernersson, S. (2021) Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Developmental and comparative immunology. 127:104273
- Meng, H., Shang, Y., Cheng, Y., Wang, K., Yu, J., Cao, P., Fan, S., Li, Y., Cui, J. (2021) Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Biochemical and Biophysical Research Communications. 551:93-99
- Murdoch, C.C., Espenschied, S.T., Matty, M.A., Mueller, O., Tobin, D.M., Rawls, J.F. (2019) Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. PLoS pathogens. 15:e1007381
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z. (2017) LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 44(6):307-317
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mohseny, A.B., Xiao, W., Carvalho, R., Spaink, H.P., Hogendoorn, P.C., and Cleton-Jansen, AM. (2012) An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. The Journal of pathology. 227(2):245-253
- Lyons, P.J., Ma, L.H., Baker, R., and Fricker, L.D. (2010) Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. PLoS One. 5(9):e12967
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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