Gene
syk
- ID
- ZDB-GENE-040702-3
- Name
- spleen tyrosine kinase
- Symbol
- syk Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to localize to cytoplasm. Orthologous to human SYK (spleen associated tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Christie et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency 82 with systemic inflammation | 619381 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035838 | SYK/ZAP-70, N-terminal SH2 domain |
| Family | IPR012234 | Tyrosine-protein kinase, non-receptor SYK/ZAP-70 |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR023420 | Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SYK/ZAP-70, N-terminal SH2 domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, non-receptor SYK/ZAP-70 | Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QFU7
|
585 | |||||||||||
|
UniProtKB:A0A8M2B201
|
608 |
Interactions and Pathways
No data available
Plasmids
No data available