Gene
ren
- ID
- ZDB-GENE-040630-3
- Name
- renin
- Symbol
- ren Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in angiotensin maturation. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in artery; embryonic structure; intermediate mesoderm; and renal system. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease 4; essential hypertension; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant tubulointerstitial kidney disease 4 | Alliance | Tubulointerstitial kidney disease, autosomal dominant, 4 | 613092 |
| Renal tubular dysgenesis | 267430 | ||
| [Hyperproreninemia] |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aspartic peptidase A1 | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Peptidase family A1 domain | Renin-like domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6YA65 | InterPro | 395 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218O21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-14F20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193966 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193989 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212860 (1) | 1388 nt | ||
| Genomic | GenBank:BX537348 (1) | 207282 nt | ||
| Polypeptide | UniProtKB:Q6YA65 (1) | 395 aa |
- Apaydin, D.C., Zakarauskas-Seth, B.I., Carnevale, L., Apaydin, O., Perrotta, M., Carnevale, R., Kotini, M.P., Kotlar-Goldaper, I., Belting, H.G., Carnevale, D., Filosa, A., Sawamiphak, S. (2022) Interferon-γ drives macrophage reprogramming, cerebrovascular remodeling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload. Cardiovascular research. 119(5):1234-1249
- Hoffmann, S., Mullins, L., Rider, S., Brown, C., Buckley, C.B., Assmus, A., Li, Z., Sierra Beltran, M., Henderson, N., Del Pozo, J., De Goes Martini, A., Sequeira-Lopez, M.L.S., Gomez, R.A., Mullins, J. (2022) Comparative Studies of Renin-Null Zebrafish and Mice Provide New Functional Insights. Hypertension (Dallas, Tex. : 1979). 79(3):e56-e66
- He, L., Chen, Y., Hu, Z., Zhang, Y., Wang, Y., Wei, J., Fan, Z., Xu, J., Peng, M., Zhao, K., Zhang, H., Liu, C. (2021) Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis. Chemosphere. 278:130349
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Qiu, W., Liu, S., Chen, H., Luo, S., Xiong, Y., Wang, X., Xu, B., Zheng, C., Wang, K.J. (2020) The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms. Journal of hazardous materials. 406:124303
- Vishnolia, K.K., Hoene, C., Tarhbalouti, K., Revenstorff, J., Aherrahrou, Z., Erdmann, J. (2020) Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32. Frontiers in cardiovascular medicine. 7:135
- Pérez-Rius, C., Castellanos, A., Gaitán-Peñas, H., Navarro, A., Artuch, R., Barrallo-Gimeno, A., Estévez, R. (2019) Role of zebrafish ClC-K/barttin channels in apical kidney chloride reabsorption. The Journal of physiology. 597(15):3969-3983
- Schaeffer, C., Izzi, C., Vettori, A., Pasqualetto, E., Cittaro, D., Lazarevic, D., Caridi, G., Gnutti, B., Mazza, C., Jovine, L., Scolari, F., Rampoldi, L. (2019) Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein. Scientific Reports. 9:11601
- Buckley, C., Carvalho, M.T., Young, L.K., Rider, S.A., McFadden, C., Berlage, C., Verdon, R.F., Taylor, J.M., Girkin, J.M., Mullins, J.J. (2017) Precise spatio-temporal control of rapid optogenetic cell ablation with mem-KillerRed in Zebrafish. Scientific Reports. 7:5096
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