Gene
uts2a
- ID
- ZDB-GENE-040630-11
- Name
- urotensin 2, alpha
- Symbol
- uts2a Nomenclature History
- Previous Names
-
- UII-a
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Predicted to act upstream of or within blood vessel diameter maintenance and regulation of blood pressure. Predicted to be located in extracellular region. Is expressed in spinal cord. Human ortholog(s) of this gene implicated in gestational diabetes; hypertension; and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028540Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa37746 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44015 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001483 | Urotensin II |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Urotensin II |
|---|---|---|---|
| UniProtKB:F1QEG0 | InterPro | 125 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-223I19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193837 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193854 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212848 (1) | 723 nt | ||
| Genomic | GenBank:BX663608 (1) | 190528 nt | ||
| Polypeptide | UniProtKB:F1QEG0 (1) | 125 aa |
- Djebar, M., Anselme, I., Pezeron, G., Bardet, P.L., Cantaut-Belarif, Y., Eschstruth, A., López-Santos, D., Le Ribeuz, H., Jenett, A., Khoury, H., Veziers, J., Parmentier, C., Hirschler, A., Carapito, C., Bachmann-Gagescu, R., Schneider-Maunoury, S., Vesque, C. (2024) Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction. eLIFE. 13:
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Alejevski, F., Leemans, M., Gaillard, A.L., Leistenschneider, D., de Flori, C., Bougerol, M., Le Mével, S., Herrel, A., Fini, J.B., Pézeron, G., Tostivint, H. (2021) Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod. Open Biology. 11:210065
- Kawabe, M., Hayashi, A., Komatsu, M., Inui, A., Shiozaki, K. (2021) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides. 87:102136
- Quan, F.B., Gaillard, A.L., Alejevski, F., Pézeron, G., Tostivint, H. (2021) Urotensin II-related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva. Peptides. 146:170675
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Luo, L., Chen, A., Hu, C., Lu, W. (2014) Dynamic expression pattern of corticotropin-releasing hormone, urotensin I and II genes under acute salinity and temperature challenge during early development of zebrafish. Fish physiology and biochemistry. 40(6):1877-86
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Quan, F.B., Bougerol, M., Rigour, F., Kenigfest, N.B., and Tostivint, H. (2012) Characterization of the true ortholog of the urotensin II-related peptide (URP) in teleosts. General and comparative endocrinology. 177(1):205-212
- Parmentier, C., Hameury, E., Dubessy, C., Quan, F.B., Habert, D., Calas, A., Vaudry, H., Lihrmann, I., and Tostivint, H. (2011) Occurrence of Two Distinct Urotensin II-Related Peptides in Zebrafish Provides New Insight into the Evolutionary History of the Urotensin II Gene Family. Endocrinology. 152(6):2330-2341
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