Gene
uts2b
- ID
- ZDB-GENE-040630-10
- Name
- urotensin 2, beta
- Symbol
- uts2b Nomenclature History
- Previous Names
-
- UII-b
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Predicted to act upstream of or within blood vessel diameter maintenance and regulation of blood pressure. Predicted to be located in extracellular region. Is expressed in spinal cord. Human ortholog(s) of this gene implicated in gestational diabetes; hypertension; and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001483 | Urotensin II |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Urotensin II |
|---|---|---|---|
| UniProtKB:B3DFZ3 | InterPro | 125 | |
| UniProtKB:Q7ZZY8 | InterPro | 125 | |
| UniProtKB:A0A8M9QLJ3 | InterPro | 83 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-138E4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193757 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193774 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205591 (1) | 581 nt | ||
| Genomic | GenBank:AL929204 (1) | 157519 nt | ||
| Polypeptide | UniProtKB:B3DFZ3 (1) | 125 aa |
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Alejevski, F., Leemans, M., Gaillard, A.L., Leistenschneider, D., de Flori, C., Bougerol, M., Le Mével, S., Herrel, A., Fini, J.B., Pézeron, G., Tostivint, H. (2021) Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod. Open Biology. 11:210065
- Kawabe, M., Hayashi, A., Komatsu, M., Inui, A., Shiozaki, K. (2021) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides. 87:102136
- Quan, F.B., Gaillard, A.L., Alejevski, F., Pézeron, G., Tostivint, H. (2021) Urotensin II-related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva. Peptides. 146:170675
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Mokalled, M.H., Patra, C., Dickson, A.L., Endo, T., Stainier, D.Y., Poss, K.D. (2016) Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Science (New York, N.Y.). 354:630-634
- Luo, L., Chen, A., Hu, C., Lu, W. (2014) Dynamic expression pattern of corticotropin-releasing hormone, urotensin I and II genes under acute salinity and temperature challenge during early development of zebrafish. Fish physiology and biochemistry. 40(6):1877-86
- Quan, F.B., Bougerol, M., Rigour, F., Kenigfest, N.B., and Tostivint, H. (2012) Characterization of the true ortholog of the urotensin II-related peptide (URP) in teleosts. General and comparative endocrinology. 177(1):205-212
- Parmentier, C., Hameury, E., Dubessy, C., Quan, F.B., Habert, D., Calas, A., Vaudry, H., Lihrmann, I., and Tostivint, H. (2011) Occurrence of Two Distinct Urotensin II-Related Peptides in Zebrafish Provides New Insight into the Evolutionary History of the Urotensin II Gene Family. Endocrinology. 152(6):2330-2341
1 - 10 of 13
Show