Gene
msrb3
- ID
- ZDB-GENE-040625-74
- Name
- methionine sulfoxide reductase B3
- Symbol
- msrb3 Nomenclature History
- Previous Names
-
- wu:fc07g04
- zgc:86909
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable peptide-methionine (R)-S-oxide reductase activity. Acts upstream of or within inner ear development. Predicted to be active in cytoplasm. Is expressed in heart rudiment; heart tube; inner ear; and myotome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6905546 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Shen et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa26254 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-msrb3 | (3) | |
| CRISPR2-msrb3 | Lin et al., 2025 | |
| CRISPR3-msrb3 | Lin et al., 2025 | |
| CRISPR4-msrb3 | Lin et al., 2025 | |
| MO1-msrb3 | N/A | Shen et al., 2015 |
| MO2-msrb3 | N/A | Shen et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 74 | Alliance | Deafness, autosomal recessive 74 | 613718 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mss4-like superfamily | Peptide methionine sulfoxide reductase MsrB | Peptide methionine sulphoxide reductase MrsB domain |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1P8M4 | InterPro | 200 | |||
| UniProtKB:Q5TZH8 | InterPro | 187 | |||
| UniProtKB:Q5TZH6 | InterPro | 186 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6A5 | ZFIN Curated Data | |
| Encodes | EST | fc07g04 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6905546 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86909 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001320378 (1) | 2316 nt | ||
| Genomic | GenBank:BX119963 (1) | 229125 nt | ||
| Polypeptide | UniProtKB:A0A8M1P8M4 (1) | 200 aa |
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Carrington, B., Varshney, G.K., Burgess, S.M., Sood, R. (2015) CRISPR-STAT: an easy and reliable PCR-based method to evaluate target-specific sgRNA activity. Nucleic acids research. 43(22):e157
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Manchenkov, T., Pasillas, M.P., Haddad, G.G., Imam, F.B. (2015) Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 5(6):1107-16
- Shen, X., Liu, F., Wang, Y., Wang, H., Ma, J., Xia, W., Zhang, J., Jiang, N., Sun, S., Wang, X., Ma, D. (2015) Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish. The International journal of developmental biology. 59:195-203
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Zhang, Y., Liang, J., Zhang, L., Wang, L., Liu, X., Yan, H., Zhao, K., Shi, H., Zhang, T., Li, N., Pu, L., Wang, L. (2015) Porcine methionine sulfoxide reductase B3: molecular cloning, tissue-specific expression profiles, and polymorphisms associated with ear size in Sus scrofa. Journal of animal science and biotechnology. 6:60
- Gavriouchkina, D., Fischer, S., Ivacevic, T., Stolte, J., Benes, V., and Dekens, M.P. (2010) Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS One. 5(9):e12542
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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