trnt1

ID

ZDB-GENE-040625-176

Name

tRNA nucleotidyl transferase, CCA-adding, 1

Symbol

trnt1 Nomenclature History

Previous Names

zgc:86645

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable CCACCA tRNA nucleotidyltransferase activity and tRNA binding activity. Involved in tRNA 3'-terminal CCA addition. Acts upstream of or within several processes, including tRNA processing; thigmotaxis; and visual behavior. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion and nucleus. Is expressed in brain; heart; pectoral fin; retina; and trunk. Used to study sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6893785 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trnt1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay	Alliance	Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay	616084
		Retinitis pigmentosa and erythrocytic microcytosis	616959

Associated With trnt1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay	trnt1^hg39/hg39	standard conditions	Giannelou et al., 2018
sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay	trnt1^hg38/hg38	standard conditions	Giannelou et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002646	Poly A polymerase, head domain
Domain	IPR032828	tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain
Family	IPR050264	Bacterial CCA-adding enzyme type 3 subfamily
Homologous_superfamily	IPR043519	Nucleotidyltransferase superfamily