Gene
cav2
- ID
- ZDB-GENE-040625-164
- Name
- caveolin 2
- Symbol
- cav2 Nomenclature History
- Previous Names
-
- wu:fc52e01
- zgc:86696
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable molecular adaptor activity and protein kinase binding activity. Predicted to be involved in several processes, including caveola assembly; insulin receptor signaling pathway; and negative regulation of endothelial cell proliferation. Predicted to be located in Golgi membrane and caveola. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to colocalize with focal adhesion. Is expressed in male organism. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001612 | Caveolin |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Caveolin |
|---|---|---|---|
| UniProtKB:Q6IQM8 | InterPro | 162 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226K23 | ZFIN Curated Data | |
| Encodes | EST | fc52e01 | ||
| Encodes | cDNA | MGC:86696 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174397 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002150 (1) | 1721 nt | ||
| Genomic | GenBank:DP000237 (1) | 468356 nt | ||
| Polypeptide | UniProtKB:Q6IQM8 (1) | 162 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CAV2 | 7 | Amino acid sequence comparison (1) |
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Atienzar-Aroca, R., Ferre-Fernández, J.J., Tevar, A., Bonet-Fernández, J.M., Cabañero, M.J., Ruiz-Pastor, M.J., Cuenca, N., Aroca-Aguilar, J.D., Escribano, J. (2022) Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish. International Journal of Molecular Sciences. 23(17)
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Lo, H.P., Lim, Y.W., Xiong, Z., Martel, N., Ferguson, C., Ariotti, N., Giacomotto, J., Rae, J., Floetenmeyer, M., Moradi, S.V., Gao, Y., Tillu, V.A., Xia, D., Wang, H., Rahnama, S., Nixon, S.J., Bastiani, M., Day, R.D., Smith, K.A., Palpant, N.J., Johnston, W.A., Alexandrov, K., Collins, B.M., Hall, T.E., Parton, R.G. (2021) Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. The Journal of cell biology. 220(12)
- Grivas, D., González-Rajal, Á., Guerrero Rodríguez, C., Garcia, R., de la Pompa, J.L. (2020) Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart. Scientific Reports. 10:12816
- Lim, Y.W., Lo, H.P., Ferguson, C., Martel, N., Giacomotto, J., Gomez, G.A., Yap, A.S., Hall, T.E., Parton, R.G. (2017) Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development. Current biology : CB. 27(13):1968-1981.e7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nixon, S.J., Wegner, J., Ferguson, C., Méry, P.F., Hancock, J.F., Currie, P.D., Key, B., Westerfield, M., and Parton, R.G. (2005) Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning. Human molecular genetics. 14(13):1727-1743
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Thomas, J.W., Touchman, J.W., Blakesley, R.W., Bouffard, G.G., Beckstrom-Sternberg, S.M., Margulies, E.H., Blanchette, M., Siepel, A.C., Thomas, P.J., McDowell, J.C., Maskeri, B., Hansen, N.F., Schwartz, M.S., Weber, R.J., Kent, W.J., Karolchik, D., Bruen, T.C., Bevan, R., Cutler, D.J., Schwartz, S., Elnitski, L., Idol, J.R., Prasad, A.B., Lee-Lin, S.Q., Maduro, V.V., Summers, T.J., Portnoy, M.E., Dietrich, N.L., Akhter, N., Ayele, K., Benjamin, B., Cariaga, K., Brinkley, C.P., Brooks, S.Y., Granite, S., Guan, X., Gupta, J., Haghighi, P., Ho, S.L., Huang, M.C., Karlins, E., Laric, P.L., Legaspi, R., Lim, M.J., Maduro, Q.L., Masiello, C.A., Mastrian, S.D., McCloskey, J.C., Pearson, R., Stantripop, S., Tiongson, E.E., Tran, J.T., Tsurgeon, C., Vogt, J.L., Walker, M.A., Wetherby, K.D., Wiggins, L.S., Young, A.C., Zhang, L.H., Osoegawa, K., Zhu, B., Zhao, B., Shu, C.L., De Jong, P.J., Lawrence, C.E., Smit, A.F., Chakravarti, A., Haussler, D., Green, P., Miller, W., and Green, E.D. (2003) Comparative analyses of multi-species sequences from targeted genomic regions. Nature. 424(6950):788-793
1 - 10 of 11
Show