ZFIN is now using GRCz12tu for Genomic Data
Gene
guk1a
- ID
- ZDB-GENE-040625-130
- Name
- guanylate kinase 1a
- Symbol
- guk1a Nomenclature History
- Previous Names
-
- sb:cb295
- zgc:86776
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GMP kinase activity. Predicted to be involved in GDP metabolic process; GMP metabolic process; and nucleoside monophosphate phosphorylation. Predicted to be located in photoreceptor inner segment. Predicted to be active in cytosol. Is expressed in cardiovascular system; neural tube; polster; spinal cord; and yolk syncytial layer. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb295 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome-21 | Alliance | Mitochondrial DNA depletion syndrome 21 | 621071 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Family | IPR017665 | Guanylate kinase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QGR9 | InterPro | 208 | |||||
| UniProtKB:A0A2R8RJH6 | InterPro | 211 | |||||
| UniProtKB:Q6IQG1 | InterPro | 199 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers