Gene
zic4
- ID
- ZDB-GENE-040622-4
- Name
- zic family member 4
- Symbol
- zic4 Nomenclature History
- Previous Names
-
- fj36d02
- wu:fj36d02
- zgc:154123
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell proliferation in hindbrain and fourth ventricle development. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural keel; central nervous system; hindbrain neural rod; lateral plate mesoderm; and neural plate. Orthologous to human ZIC4 (Zic family member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143637 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-zic4 | N/A | Elsen et al., 2008 |
| MO2-zic4 | N/A | Elsen et al., 2008 |
| MO3-zic4 | N/A | Elsen et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type zinc-finger protein GLI-like | ZIC1-5/GLI1-3like, C2H2 zinc finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PU73 | InterPro | 375 | |||||
| UniProtKB:B2BM15 | InterPro | 494 | |||||
| UniProtKB:Q08BV0 | InterPro | 466 | |||||
| UniProtKB:A0A8M1NAP2 | InterPro | 530 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-95F4 | ZFIN Curated Data | |
| Encodes | EST | fj36d02 | ||
| Encodes | EST | IMAGE:7143637 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:154123 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076612 (1) | 2513 nt | ||
| Genomic | GenBank:CU138554 (1) | 44770 nt | ||
| Polypeptide | UniProtKB:A0A8M1NAP2 (1) | 530 aa |
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Trivellin, G., Tirosh, A., Hernández-Ramírez, L.C., Gupta, T., Tsai-Morris, C.H., Faucz, F.R., Burgess, H.A., Feldman, B., Stratakis, C.A. (2020) The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish. Molecular and Cellular Endocrinology. 520:111091
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
- Elsen, G.E., Choi, L.Y., Millen, K.J., Grinblat, Y., and Prince, V.E. (2008) Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Developmental Biology. 314(2):376-392
- Keller, M.J., and Chitnis, A.B. (2007) Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Development genes and evolution. 217(7):541-547
- Rohrschneider, M.R., Elsen, G.E., and Prince, V.E. (2007) Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Developmental Biology. 309(2):358-372
- Ohtsuka, M., Kikuchi, N., Ozato, K., Inoko, H., and Kimura, M. (2004) Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse. Genomics. 83(6):1063-1071
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