Gene

tp53bp2a

ID

ZDB-GENE-040516-8

Name

tumor protein p53 binding protein, 2a

Symbol

tp53bp2a Nomenclature History

Previous Names

aspp2a (1)
tp53bp2
wu:fa09h08
wu:fb04e08
zgc:85720

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have p53 binding activity. Involved in chordate embryonic development and negative regulation of protein kinase B signaling. Predicted to localize to nucleus. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liu et al., 2014

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tp53bp2a Human Ortholog

No data available

Associated With tp53bp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000159	Ras-associating domain
Domain	IPR001452	SH3 domain
Domain	IPR048945	Ras association domain-containing protein 8/10, RA domain
Family	IPR047163	Apoptosis-stimulating of p53 protein 1/2
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat