Gene

ubap1

ID
ZDB-GENE-040426-950
Name
ubiquitin associated protein 1
Symbol
ubap1 Nomenclature History
Previous Names
  • zgc:56228
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable ubiquitin binding activity. Acts upstream of or within axon extension. Predicted to be located in cytosol and endosome. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 80. Orthologous to human UBAP1 (ubiquitin associated protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fcc143GtTransgenic insertionUnknownSplicing VariantDNA
sa37251Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-ubap1N/ASeiler et al., 2015
MO2-ubap1N/ALin et al., 2019
MO3-ubap1N/ALin et al., 2019
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Human Disease
Associated With ubap1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 80 Alliance Spastic paraplegia 80, autosomal dominant 618418
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Associated With ubap1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015940 Ubiquitin-associated domain
Domain IPR023340 UMA domain
Domain IPR049467 Ubiquitin-associated protein 1-like, UBA2 domain
Family IPR038870 Ubiquitin-associated protein 1
Homologous_superfamily IPR009060 UBA-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length UBA-like superfamily Ubiquitin-associated domain Ubiquitin-associated protein 1 Ubiquitin-associated protein 1, C-terminal Ubiquitin-associated protein 1-like, UBA2 domain UMA domain
UniProtKB:F6P6X0 InterPro 453
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 21
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ubap1-201 (1) Ensembl 4,989 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-89G21ZFIN Curated Data
EncodescDNAMGC:56228ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanUBAP19
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseUbap14
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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