Gene

kbtbd4

ID

ZDB-GENE-040426-937

Name

kelch repeat and BTB (POZ) domain containing 4

Symbol

kbtbd4 Nomenclature History

Previous Names

zgc:56204 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Orthologous to human KBTBD4 (kelch repeat and BTB domain containing 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56204 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa36636	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With kbtbd4 Human Ortholog

No data available

Associated With kbtbd4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR011705	BTB/Kelch-associated
Domain	IPR042949	KBTBD4, BTB/POZ domain
Domain	IPR042950	KBTBD4, BACK domain
Family	IPR017096	BTB-kelch protein

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Domain Details Per Protein

Protein	Additional Resources	Length	BTB/Kelch-associated	BTB-kelch protein	BTB/POZ domain	KBTBD4, BACK domain	KBTBD4, BTB/POZ domain	Kelch repeat and BTB domain-containing protein 4	Kelch-type beta propeller	SKP1/BTB/POZ domain superfamily
UniProtKB:Q7ZV61	InterPro	522

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 18

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kbtbd4-201 (1) Ensembl	Ensembl		1,734 nt	Select Tool ZFIN BLAST
mRNA	kbtbd4-202 (1) Ensembl	Ensembl		5,249 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-45F10	BX942814	ZFIN Curated Data
Encodes	cDNA	MGC:56204	BC045989	ZFIN Curated Data
Encodes	cDNA	MGC:174094	BC152675	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200209 (1)	1776 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX469889 (1)	177975 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZV61 (1)	522 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	KBTBD4	11	Ensembl:ENSG00000284900 Gene:55709 HGNC:23761 OMIM:617645	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Kbtbd4	2	Ensembl:ENSMUSG00000005505 Gene:67136 MGI:1914386	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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