Gene
parn
- ID
- ZDB-GENE-040426-880
- Name
- poly(A)-specific ribonuclease (deadenylation nuclease)
- Symbol
- parn Nomenclature History
- Previous Names
-
- zgc:56067
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity; cation binding activity; and poly(A)-specific ribonuclease activity. Involved in hemopoiesis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56067 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dhanraj et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive dyskeratosis congenita 6 | Alliance | Dyskeratosis congenita, autosomal recessive 6 | 616353 |
| Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4 | 616371 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001374 | R3H domain |
| Domain | IPR014789 | Poly(A)-specific ribonuclease, RNA-binding |
| Domain | IPR034042 | PARN, R3H domain |
| Family | IPR006941 | Ribonuclease CAF1 |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR036867 | R3H domain superfamily |
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | PARN, R3H domain | Poly(A)-specific ribonuclease, RNA-binding | R3H domain | R3H domain superfamily | Ribonuclease CAF1 | Ribonuclease H-like superfamily | Ribonuclease H superfamily | RNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IHL6
|
647 | |||||||||
|
UniProtKB:A0A0R4IW61
|
660 | |||||||||
|
UniProtKB:Q7ZU92
|
660 |
Interactions and Pathways
No data available
Plasmids
No data available