Gene

parn

ID
ZDB-GENE-040426-880
Name
poly(A)-specific ribonuclease (deadenylation nuclease)
Symbol
parn Nomenclature History
Previous Names
  • zgc:56067
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Is predicted to enable RNA binding activity; cation binding activity; and poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening. Acts upstream of or within hemopoiesis. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Dhanraj et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With parn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive dyskeratosis congenita 6 Alliance Dyskeratosis congenita, autosomal recessive 6 616353
Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4 616371
Associated With parn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001374 R3H domain
Domain IPR014789 Poly(A)-specific ribonuclease, RNA-binding
Domain IPR034042 PARN, R3H domain
Family IPR006941 Ribonuclease CAF1
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Homologous_superfamily IPR036397 Ribonuclease H superfamily
Homologous_superfamily IPR036867 R3H domain superfamily
Domain Details Per Protein
Protein Length Nucleotide-binding alpha-beta plait domain superfamily PARN, R3H domain Poly(A)-specific ribonuclease, RNA-binding R3H domain R3H domain superfamily Ribonuclease CAF1 Ribonuclease H-like superfamily Ribonuclease H superfamily RNA-binding domain superfamily
UniProtKB:A0A0R4IX97 95
UniProtKB:Q7ZU92 660
UniProtKB:A0A0R4IHL6 647
UniProtKB:A0A0R4IW61 660
UniProtKB:A0A0R4IYB9 193
UniProtKB:A0A0R4IPV8 91
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations