Gene
wwox
- ID
- ZDB-GENE-040426-858
- Name
- WW domain containing oxidoreductase
- Symbol
- wwox Nomenclature History
- Previous Names
-
- zgc:55975 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have oxidoreductase activity. Involved in cellular calcium ion homeostasis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; early infantile epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Is expressed in cranial nerve II; gut; heart; and presumptive cardiac ventricle heart tube. Orthologous to human WWOX (WW domain containing oxidoreductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55975 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Tsuruwaka et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 12 | Alliance | Spinocerebellar ataxia, autosomal recessive 12 | 614322 |
| developmental and epileptic encephalopathy 28 | Alliance | Developmental and epileptic encephalopathy 28 | 616211 |
| esophageal cancer | Alliance | Esophageal squamous cell carcinoma, somatic | 133239 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase SDR | WW domain | WW domain superfamily | WWOX, classical (c)-like SDR domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q803A8
|
412 |
Interactions and Pathways
No data available
Plasmids
No data available