Gene

wwox

ID
ZDB-GENE-040426-858
Name
WW domain containing oxidoreductase
Symbol
wwox Nomenclature History
Previous Names
  • zgc:55975 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have oxidoreductase activity. Involved in cellular calcium ion homeostasis. Predicted to localize to cytoplasm and nucleus. Is expressed in cranial nerve II; gut; heart; and presumptive cardiac ventricle heart tube. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; early infantile epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Tsuruwaka et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wwox Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 12 Alliance Spinocerebellar ataxia, autosomal recessive 12 614322
developmental and epileptic encephalopathy 28 Alliance Developmental and epileptic encephalopathy 28 616211
esophageal cancer Alliance Esophageal squamous cell carcinoma, somatic 133239
Associated With wwox Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001202 WW domain
Domain IPR042732 WWOX, classical (c)-like SDR domain
Family IPR002347 Short-chain dehydrogenase/reductase SDR
Homologous_superfamily IPR036020 WW domain superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase SDR WW domain WW domain superfamily WWOX, classical (c)-like SDR domain
UniProtKB:Q803A8 412
UniProtKB:F8W4Q2 349
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations