Gene
acy1
- ID
- ZDB-GENE-040426-755
- Name
- aminoacylase 1
- Symbol
- acy1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable aminoacylase activity. Predicted to act upstream of or within amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in lens; liver; peripheral olfactory organ; pronephric duct; and pronephros. Orthologous to human ACY1 (aminoacylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55605 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa25184 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aminoacylase 1 deficiency | 609924 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacylase-1 peptidase M20A | ArgE/DapE/ACY1/CPG2/YscS, conserved site | Bacterial exopeptidase dimerisation domain | N-acyl-L-amino-acid amidohydrolase | Peptidase M20 | Peptidase M20, dimerisation domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QZ04 | InterPro | 420 | ||||||
| UniProtKB:A0A8M3ANA5 | InterPro | 427 | ||||||
| UniProtKB:A0AB32TCU7 | InterPro | 427 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-226G1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55605 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76955 | ||
| Encodes | cDNA | MGC:191982 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001272080 (1) | 2604 nt | ||
| Genomic | GenBank:CU896698 (2) | 41678 nt | ||
| Polypeptide | UniProtKB:A0A8M3ANA5 (1) | 427 aa |
- Peng, X., Dong, M., Ma, L., Jia, X.E., Mao, J., Jin, C., Chen, Y., Gao, L., Liu, X., Ma, K., Wang, L., Du, T., Jin, Y., Huang, Q., Li, K., Zon, L.I., Liu, T., Deng, M., Zhou, Y., Xi, X., Zhou, Y., Chen, S. (2015) A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 29(12):2355-65
- Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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