Gene
lin28ab
- ID
- ZDB-GENE-040426-747
- Name
- lin-28 homolog Ab
- Symbol
- lin28ab Nomenclature History
- Previous Names
-
- lin28
- lin28a
- sb:cb650
- zgc:55584 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within chordate embryonic development; negative regulation of gene expression; and regeneration. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; neural plate; and neural tube. Orthologous to human LIN28A (lin-28 homolog A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb650 (33 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb840 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la013377Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020599Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020600Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020601Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027996Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| psi37 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 7 of 7
Show
1 - 9 of 9
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cold-shock domain | Cold-shock protein Csp, DNA-binding | Lin-28A-like, second zinc knuckle | Lin-28 homolog RNA-binding protein | Nucleic acid-binding, OB-fold | Zinc finger, CCHC-type | Zinc finger, CCHC-type superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q803L0 | InterPro | 202 | |||||||
| UniProtKB:A0A2R8Q8W5 | InterPro | 207 | |||||||
| UniProtKB:I3IS11 | InterPro | 194 |
1 - 3 of 3
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lin28a-001
(1)
|
Ensembl | 2,020 nt | ||
| mRNA |
lin28a-203
(1)
|
Ensembl | 607 nt | ||
| mRNA |
lin28a-204
(1)
|
Ensembl | 547 nt | ||
| mRNA |
lin28a-206
(1)
|
Ensembl | 908 nt | ||
| mRNA |
lin28a-207
(1)
|
Ensembl | 6,269 nt |
1 - 5 of 8 Show all
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:lin28ab-2A-mCherry,myl7:EGFP) |
| 1 | Ye et al., 2020 | ||
| Tg(hsp70l:MYC-lin28ab,-1.0Cau.Tuba1:GFP) |
| 1 | Elsaeidi et al., 2018 |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232D9 | ZFIN Curated Data | |
| Encodes | EST | cb650 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55584 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201091 (1) | 1692 nt | ||
| Genomic | GenBank:BX322664 (1) | 157585 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q8W5 (1) | 207 aa |
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Xu, H., Cao, L., Chen, Y., Zhou, C., Xu, J., Zhang, Z., Li, X., Liu, L., Lu, J. (2024) Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration. Neural regeneration research. :
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Palsamy, K., Chen, J.Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., Powell, C., Goldman, D., Parent, J.M. (2023) Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 71(11):2642-2663
- Džulová, D., Lawless, D., Pinton, G.G., Renner, N.A., Schorderet, D.F. (2022) Incomplete Recovery of Zebrafish Retina Following Cryoinjury. Cells. 11(8):
- Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., Peng, L. (2022) Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Frontiers in genetics. 13:819682
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Lourenço, R., Brandão, A.S., Borbinha, J., Gorgulho, R., Jacinto, A. (2021) Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas. Frontiers in cell and developmental biology. 9:667796
- Medrano, M.P., Pisera-Fuster, A., Bernabeu, R.O., Faillace, M.P. (2020) P2X7 and A2A receptor endogenous activation protects against neuronal death caused by CoCl2 -induced photoreceptor toxicity in the zebrafish retina. The Journal of comparative neurology. 528(12):2000-2020
- Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Saran, N.K., Ramachandran, R. (2020) Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 23:100817
1 - 10 of 40
Show