ZFIN is now using GRCz12tu for Genomic Data
Gene
fzr1a
- ID
- ZDB-GENE-040426-712
- Name
- fizzy/cell division cycle 20 related 1a
- Symbol
- fzr1a Nomenclature History
- Previous Names
-
- fzr1
- zgc:55450
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to act upstream of or within cell division and positive regulation of ubiquitin protein ligase activity. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55450 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Imai et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 109 | Alliance | Developmental and epileptic encephalopathy 109 | 620145 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR056150 | CDC20/Fizzy, WD40 domain |
| Family | IPR033010 | WD repeat Cdc20/Fizzy |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CDC20/Fizzy, WD40 domain | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat Cdc20/Fizzy |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUP9 | InterPro | 495 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers