Gene

tyms

ID
ZDB-GENE-040426-59
Name
thymidylate synthetase
Symbol
tyms Nomenclature History
Previous Names
  • zgc:56465
  • zgc:77659
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits thymidylate synthase activity. Involved in dTMP biosynthetic process and retina development in camera-type eye. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Orthologous to human TYMS (thymidylate synthetase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tyms Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dyskeratosis congenita, digenic 620040
Associated With tyms Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR020940 Thymidylate synthase, active site
Domain IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain
Family IPR000398 Thymidylate synthase
Family IPR045097 Thymidylate synthase/dCMP hydroxymethylase
Homologous_superfamily IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily
Domain Details Per Protein
Protein Length Thymidylate synthase Thymidylate synthase, active site Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase domain Thymidylate synthase/dCMP hydroxymethylase superfamily
UniProtKB:Q7ZUI7 319
UniProtKB:Q6P045 318
UniProtKB:Q9DGH5 319
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations