Gene
faf1
- ID
- ZDB-GENE-040426-2863
- Name
- Fas (TNFRSF6) associated factor 1
- Symbol
- faf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable NF-kappaB binding activity and ubiquitin binding activity. Acts upstream of or within cartilage development; fin regeneration; and pharyngeal system development. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in pharyngeal arch; pharyngeal arch 1; pharyngeal arch 2; and pharyngeal arch 3-7. Orthologous to human FAF1 (Fas associated factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149405 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ghassibe-Sabbagh et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-faf1 | N/A | Ghassibe-Sabbagh et al., 2011 |
| MO2-faf1 | N/A | Ghassibe-Sabbagh et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FAF1, UBA-like domain | Fas-associated factor 1/2-like, UAS domain | FAS-associated factor 1-like, UBX domain | Thioredoxin-like superfamily | UAS | Ubiquitin-like domain | Ubiquitin-like domain superfamily | UBX domain | UBX domain-containing protein |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0UXY9 | InterPro | 675 | |||||||||
| UniProtKB:A0A8M9QIJ3 | InterPro | 674 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-349N16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-165L2 | ZFIN Curated Data | |
| Encodes | EST | fc25h12 | ||
| Encodes | EST | IMAGE:7149405 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55752 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212973 (1) | 2961 nt | ||
| Genomic | GenBank:CR388216 (2) | 134478 nt | ||
| Polypeptide | UniProtKB:B0UXY9 (1) | 675 aa |
- Ma, Z., Zhu, P., Pang, M., Guo, L., Chang, N., Zheng, J., Zhu, X., Gao, C., Huang, H., Cui, Z., Xiong, J.W., Peng, J., Chen, J. (2017) A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Scientific Reports. 7:10381
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xu, S., Xia, W., Zohar, Y., and Gui, J.F. (2013) Zebrafish dmrta2 Regulates the Expression of cdkn2c in Spermatogenesis in the Adult Testis. Biology of reproduction. 88(1):14
- Ghassibe-Sabbagh, M., Desmyter, L., Langenberg, T., Claes, F., Boute, O., Bayet, B., Pellerin, P., Hermans, K., Backx, L., Mansilla, M.A., Imoehl, S., Nowak, S., Ludwig, K.U., Baluardo, C., Ferrian, M., Mossey, P.A., Noethen, M., Dewerchin, M., François, G., Revencu, N., Vanwijck, R., Hecht, J., Mangold, E., Murray, J., Rubini, M., Vermeesch, J.R., Poirel, H.A., Carmeliet, P., and Vikkula, M. (2011) FAF1, a Gene that Is Disrupted in Cleft Palate and Has Conserved Function in Zebrafish. American journal of human genetics. 88(2):150-161
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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