Gene

map2k1

ID
ZDB-GENE-040426-2759
Name
mitogen-activated protein kinase kinase 1
Symbol
map2k1 Nomenclature History
Previous Names
  • mek1 (1)
  • si:ch211-242m18.2
  • wu:fj56a12
  • wu:fj61b01 (1)
  • zgc:56557
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in several cellular components, including centrosome; endosome; and focal adhesion. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa6511Allele with one point mutationUnknownPremature StopENU
sa43086Allele with one point mutationUnknownPremature StopENU
1 - 2 of 2
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-map2k1
    Bu et al., 2021
    1 - 1 of 1
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    Human Disease
    Associated With map2k1 Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cardiofaciocutaneous syndrome 3 Alliance Cardiofaciocutaneous syndrome 3 615279
    melorheostosis Alliance Melorheostosis, isolated, somatic mosaic 155950
    1 - 2 of 2
    Associated With map2k1 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Family IPR050915 MAP kinase kinase
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    1 - 5 of 5
    Domain Details Per Protein
    Protein Additional Resources Length MAP kinase kinase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
    UniProtKB:Q4V947 InterPro 395
    1 - 1 of 1
    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 18
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA map2k1-201 (1) Ensembl 2,093 nt
    1 - 1 of 1
    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    Construct Regulatory Region Coding Sequence Species Tg Lines Citations
    Tg(hsp70l:dnmap2k1K98M,cryaa:EGFP)
    • Danio rerio
    1Liu et al., 2017
    Tg(hsp70l:map2k1,myl7:EGFP)
    • Danio rerio
    1 (2)
    Tg(hsp70l:map2k1_S219D_S223D,myl7:EGFP)
    • Danio rerio
    1 (2)
    1 - 3 of 3
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    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACCH73-94F11ZFIN Curated Data
    Contained inBACCH211-242M18ZFIN Curated Data
    EncodesESTfj56a12
    EncodesESTfj61b01
    EncodescDNAMGC:56557ZFIN Curated Data
    EncodescDNAMGC:113988ZFIN Curated Data
    1 - 6 of 6
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanMAP2K115
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (3)
    Phylogenetic tree (1)
    MouseMap2k19
    Phylogenetic tree (1)
    Citations
    1 - 10 of 16
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