Gene
map2k1
- ID
- ZDB-GENE-040426-2759
- Name
- mitogen-activated protein kinase kinase 1
- Symbol
- map2k1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in several cellular components, including centrosome; endosome; and focal adhesion. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cardiofaciocutaneous syndrome 3 | Alliance | Cardiofaciocutaneous syndrome 3 | 615279 |
| melorheostosis | Alliance | Melorheostosis, isolated, somatic mosaic | 155950 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050915 | MAP kinase kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | MAP kinase kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q4V947 | InterPro | 395 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map2k1-201
(1)
|
Ensembl | 2,093 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:dnmap2k1K98M,cryaa:EGFP) |
|
| 1 | Liu et al., 2017 | |
| Tg(hsp70l:map2k1,myl7:EGFP) |
|
| 1 | (2) | |
| Tg(hsp70l:map2k1_S219D_S223D,myl7:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-94F11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-242M18 | ZFIN Curated Data | |
| Encodes | EST | fj56a12 | ||
| Encodes | EST | fj61b01 | ||
| Encodes | cDNA | MGC:56557 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113988 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213419 (1) | 2115 nt | ||
| Genomic | GenBank:CT863714 (2) | 62423 nt | ||
| Polypeptide | UniProtKB:Q4V947 (1) | 395 aa |
- Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315
- Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
- Picton, L.D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E.R., Iacoviello, F., Shearing, P.R., El Manira, A. (2021) A spinal organ of proprioception for integrated motor action feedback. Neuron. 109(7):1188-1201.e7
- Liyanage, T.D., Nikapitiya, C., Lee, J., De Zoysa, M. (2020) Molecular insight into regulation of miRNA in the spleen of zebrafish (Danio rerio) upon pathogenic Streptococcus parauberis infection. Fish & shellfish immunology. 106:898-909
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Liu, P., Zhong, T.P. (2017) MAPK/ERK signalling is required for zebrafish cardiac regeneration. Biotechnology Letters. 39(7):1069-1077
- Sertori, R., Liongue, C., Basheer, F., Lewis, K.L., Rasighaemi, P., de Coninck, D., Traver, D., Ward, A.C. (2016) Conserved IL-2Rγc Signaling Mediates Lymphopoiesis in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 196(1):135-43
- Yuan, Y., Zhang, J., Zhou, Q. (2016) Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43:99-102
- Chou, C.M., Chen, Y.C., Su, S., Chen, G.D., Huang, K.Y., Lien, H.W., Huang, C.J., Cheng, C.H. (2015) Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Journal of Biomedical Science. 22:102
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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