Gene
elovl1b
- ID
- ZDB-GENE-040426-2755
- Name
- ELOVL fatty acid elongase 1b
- Symbol
- elovl1b Nomenclature History
- Previous Names
-
- wu:fj32h05
- zgc:56567 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid elongase activity. Acts upstream of or within kidney development and swim bladder development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; fin; nervous system; periderm; and pleuroperitoneal region. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56567 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Bhandari et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017672Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa21866 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3817 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-elovl1b | Sun et al., 2021 | |
| MO1-elovl1b | N/A | Bhandari et al., 2016 |
| MO2-elovl1b | N/A | Bhandari et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facies | 618527 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ELO family | Elongation of very long chain fatty acids protein 1 |
|---|---|---|---|---|
| UniProtKB:A0A0R4IT00 | InterPro | 320 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
elovl1b-201
(1)
|
Ensembl | 1,119 nt | ||
| mRNA |
elovl1b-202
(1)
|
Ensembl | 893 nt | ||
| mRNA |
elovl1b-203
(1)
|
Ensembl | 721 nt | ||
| mRNA |
elovl1b-204
(1)
|
Ensembl | 575 nt | ||
| mRNA |
elovl1b-205
(1)
|
Ensembl | 1,818 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-231N3 | ZFIN Curated Data | |
| Encodes | EST | fj32h05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56567 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174547 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328594 (1) | 1987 nt | ||
| Genomic | GenBank:CR847923 (1) | 88835 nt | ||
| Polypeptide | UniProtKB:A0A0R4IT00 (1) | 320 aa |
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870
- Raas, Q., van de Beek, M.C., Forss-Petter, S., Dijkstra, I.M., DeSchiffart, A., Freshner, B.C., Stevenson, T.J., Jaspers, Y.R., Nagtzaam, L.M., Wanders, R.J., van Weeghel, M., Engelen-Lee, J.Y., Engelen, M., Eichler, F., Berger, J., Bonkowsky, J.L., Kemp, S. (2021) Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy. The Journal of Clinical Investigation. 131(8):
- Sun, S., Cao, X., Gao, J. (2021) C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage. iScience. 24:103409
- Bhandari, S., Lee, J.N., Kim, Y.I., Nam, I.K., Kim, S.J., Kim, S.J., Kwak, S., Oh, G.S., Kim, H.J., Yoo, H.J., So, H.S., Choe, S.K., Park, R. (2016) The fatty acid chain elongase, Elovl1, is required for kidney and swim bladder development during zebrafish embryogenesis. Organogenesis. 12(2):78-93
- Azuaje, F.J. (2014) Selecting biologically informative genes in co-expression networks with a centrality score. Biology Direct. 9:12
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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