Gene
eef1da
- ID
- ZDB-GENE-040426-2740
- Name
- eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
- Symbol
- eef1da Nomenclature History
- Previous Names
-
- eef1d
- elongation factor-1
- zgc:66406 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111981 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015014Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa25926 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33051 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39949 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language | 621150 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001326 | Translation elongation factor EF1B, beta/delta chains, conserved site |
| Domain | IPR014038 | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain |
| Domain | IPR018940 | Elongation factor 1 beta central acidic region, eukaryote |
| Family | IPR049720 | Translation elongation factor EF1B, beta/delta subunit |
| Homologous_superfamily | IPR014717 | Translation elongation factor EF1B/small ribosomal subunit protein bS6 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Elongation factor 1 beta central acidic region, eukaryote | Translation elongation factor eEF-1beta-like superfamily | Translation elongation factor EF1B, beta/delta chains, conserved site | Translation elongation factor EF1B, beta/delta subunit | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain | Translation elongation factor EF1B/small ribosomal subunit protein bS6 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z1P2 | InterPro | 463 | ||||||
| UniProtKB:A0A8M9QAS6 | InterPro | 441 | ||||||
| UniProtKB:A0A8M9QP05 | InterPro | 439 | ||||||
| UniProtKB:A0A8M2BAS2 | InterPro | 291 | ||||||
| UniProtKB:A0A8M2BAP5 | InterPro | 267 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eef1da-201
(1)
|
Ensembl | 935 nt | ||
| mRNA |
eef1da-202
(1)
|
Ensembl | 492 nt | ||
| mRNA |
eef1da-203
(1)
|
Ensembl | 458 nt | ||
| mRNA |
eef1da-204
(1)
|
Ensembl | 813 nt | ||
| mRNA |
eef1da-205
(1)
|
Ensembl | 845 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-249O11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111981 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192617 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:66406 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177453 (1) | 903 nt | ||
| Genomic | GenBank:BX255896 (1) | 150289 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z1P2 (1) | 463 aa |
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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