Gene
cdc45
- ID
- ZDB-GENE-040426-2710
- Name
- CDC45 cell division cycle 45 homolog (S. cerevisiae)
- Symbol
- cdc45 Nomenclature History
- Previous Names
-
- cdc45l
- wu:fi05h01
- zgc:56264 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in several processes, including DNA-dependent DNA replication; double-strand break repair via break-induced replication; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to localize to DNA replication preinitiation complex; nuclear pre-replicative complex; and replication fork protection complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56264 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 7 | Alliance | Meier-Gorlin syndrome 7 | 617063 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR003874 | CDC45 family |
Domain Details Per Protein
| Protein | Length | CDC45 family |
|---|---|---|
|
UniProtKB:Q7ZU79
|
572 |
Interactions and Pathways
No data available
Plasmids
No data available