Gene
tmem161b
- ID
- ZDB-GENE-040426-2693
- Name
- transmembrane protein 161B
- Symbol
- tmem161b Nomenclature History
- Previous Names
-
- id:ibd2207
- wu:fc31d04
- zgc:63626
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Involved in regulation of cardiac muscle cell action potential and regulation of heart rate. Acts upstream of or within regulation of cardiac muscle contraction by calcium ion signaling. Located in plasma membrane. Is expressed in adaxial cell; head; mucus secreting cell; pronephric duct; and pronephros. Orthologous to human TMEM161B (transmembrane protein 161B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63626 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Koopman et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20522 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33701 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uq4ks | Allele with one point mutation | Exon 12 | Premature Stop | not specified | |
| uq5ks | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019395 | Transmembrane protein 161A/B |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Transmembrane protein 161A/B |
|---|---|---|---|
| UniProtKB:Q7SY10 | InterPro | 484 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tmem161b-201
(1)
|
Ensembl | 3,502 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(tmem161b:tmem161b-Citrine) |
|
|
| 1 | Koopman et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-195M1 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-52E4 | ZFIN Curated Data | |
| Encodes | EST | fc31d04 | ZFIN Curated Data | |
| Encodes | EST | ibd2207 | ||
| Encodes | cDNA | MGC:63626 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213371 (1) | 3509 nt | ||
| Genomic | GenBank:BX470189 (1) | 183070 nt | ||
| Polypeptide | UniProtKB:Q7SY10 (1) | 484 aa |
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Koopman, C.D., De Angelis, J., Iyer, S.P., Verkerk, A.O., Da Silva, J., Berecki, G., Jeanes, A., Baillie, G.J., Paterson, S., Uribe, V., Ehrlich, O.V., Robinson, S.D., Garric, L., Petrou, S., Simons, C., Vetter, I., Hogan, B.M., de Boer, T.P., Bakkers, J., Smith, K.A. (2021) The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Proceedings of the National Academy of Sciences of the United States of America. 118(9):
- Espino-Saldaña, A.E., Durán-Ríos, K., Olivares-Hernandez, E., Rodríguez-Ortiz, R., Arellano-Carbajal, F., Martínez-Torres, A. (2020) Temporal and spatial expression of zebrafish mctp genes and evaluation of frameshift alleles of mctp2b. Gene. 738:144371
- Madelaine, R., Notwell, J.H., Skariah, G., Halluin, C., Chen, C.C., Bejerano, G., Mourrain, P. (2018) A screen for deeply conserved non-coding GWAS SNPs uncovers a MIR-9-2 functional mutation associated to retinal vasculature defects in human. Nucleic acids research. 46(7):3517-3531
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kikuta, H., Laplante, M., Navratilova, P., Komisarczuk, A.Z., Engstrom, P.G., Fredman, D., Akalin, A., Caccamo, M., Sealy, I., Howe, K., Ghislain, J., Pezeron, G., Mourrain, P., Ellingsen, S., Oates, A.C., Thisse, C., Thisse, B., Foucher, I., Adolf, B., Geling, A., Lenhard, B., and Becker, T.S. (2007) Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome research. 17(5):545-555
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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