Gene
psmb3
- ID
- ZDB-GENE-040426-2682
- Name
- proteasome 20S subunit beta 3
- Symbol
- psmb3 Nomenclature History
- Previous Names
-
- proteasome (prosome, macropain) subunit,
- wu:fb11d10
- wu:fu88b08
- zgc:56374
- zgc:92596
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB3 (proteasome 20S subunit beta 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141089 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR016050 | Proteasome beta-type subunit, conserved site |
Family | IPR001353 | Proteasome, subunit alpha/beta |
Family | IPR023333 | Proteasome B-type subunit |
Family | IPR033811 | Proteasome beta 3 subunit |
Homologous_superfamily | IPR029055 | Nucleophile aminohydrolases, N-terminal |
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Domain Details Per Protein
Protein | Additional Resources | Length | Nucleophile aminohydrolases, N-terminal | Proteasome beta 3 subunit | Proteasome beta-type subunit, conserved site | Proteasome B-type subunit | Proteasome, subunit alpha/beta |
---|---|---|---|---|---|---|---|
UniProtKB:Q7ZUJ8 | InterPro | 205 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-193C12 | ZFIN Curated Data | |
Encodes | EST | fb11d10 | ZFIN Curated Data | |
Encodes | EST | fu88b08 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7141089 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:56374 | ZFIN Curated Data | |
Has Artifact | cDNA | MGC:92596 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001129823 (1) | 877 nt | ||
Genomic | GenBank:CU683898 (2) | 46184 nt | ||
Polypeptide | UniProtKB:Q7ZUJ8 (1) | 205 aa |
- Li, S., Li, H., Bennewitz, K., Poschet, G., Buettner, M., Hausser, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2025) Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis. Metabolism: clinical and experimental. :156149156149
- Hasan, A.M., Jyoti, M.M.S., Rana, M.R., Rezanujjaman, M., Tokumoto, T. (2022) Purification and Identification of the 20S Proteasome Complex from Zebrafish. Zebrafish. 19:18-23
- Ben-Yair, R., Butty, V.L., Busby, M., Qiu, Y., Levine, S.S., Goren, A., Boyer, L.A., Burns, C.G., Burns, C.E. (2019) H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development (Cambridge, England). 146(19):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
- Hegde, A., Qiu, N.C., Qiu, X., Ho, S.H., Tay, K.Q., George, J., Ng, F.S., Govindarajan, K.R., Gong, Z., Mathavan, S., and Jiang, Y.J. (2008) Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes. PLoS One. 3(1):e1479
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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