Gene
ggh
- ID
- ZDB-GENE-040426-2615
- Name
- gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
- Symbol
- ggh Nomenclature History
- Previous Names
-
- wu:fa56a05
- wu:fj90a01
- zgc:76958
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables gamma-glutamyl-peptidase activity. Acts upstream of or within folic acid-containing compound metabolic process. Predicted to be located in extracellular region. Predicted to be active in vacuole. Orthologous to human GGH (gamma-glutamyl hydrolase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Liang et al., 2024
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12231 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Class I glutamine amidotransferase-like | Peptidase C26 | Peptidase C26, gamma-glutamyl hydrolase |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PNR0 | InterPro | 225 | |||
| UniProtKB:Q6NY42 | InterPro PDB | 312 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-117H8 | ZFIN Curated Data | |
| Encodes | EST | fa56a05 | ZFIN Curated Data | |
| Encodes | EST | fj90a01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76958 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213322 (1) | 1372 nt | ||
| Genomic | GenBank:CR354540 (1) | 165122 nt | ||
| Polypeptide | UniProtKB:Q6NY42 (1) | 312 aa |
- Chi, W.Y., Lee, G.H., Tang, M.J., Chen, B.H., Lin, W.L., Fu, T.F. (2024) Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation. BMC Biology. 22:146146
- Liang, S., Zhang, H., Jiao, L., Shao, R., Lan, Y., Liao, X., Mai, K., Ai, Q., Wan, M. (2024) Vitamin D promotes the folate transport and metabolism in zebrafish (Danio rerio). American journal of physiology. Endocrinology and metabolism. 326(4):E482-E492
- Hsiao, T.H., Lee, G.H., Chang, Y.S., Chen, B.H., Fu, T.F. (2021) The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Frontiers in cell and developmental biology. 9:702969
- Lee, G.H., Cheng, N.W., Yu, H.H., Tsai, J.N., Liu, T., Wen, Z.H., Chen, B.H., Fu, T.F. (2019) A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance. Scientific Reports. 9:12633
- Tu, H.C., Lin, M.Y., Lin, C.Y., Hsiao, T.H., Wen, Z.H., Chen, B.H., Fu, T.F. (2019) Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish. Ecotoxicology and environmental safety. 182:109380
- Tu, H.C., Lee, G.H., Hsiao, T.H., Kao, T.T., Wang, T.Y., Tsai, J.N., Fu, T.F. (2017) One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae. PLoS One. 12:e0188585
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kao, T.T., Chu, C.Y., Lee, G.H., Hsiao, T.H., Cheng, N.W., Chang, N.S., Chen, B.H., Fu, T.F. (2014) Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish — Implication in neural tube defects and Alzheimer's diseases. Neurobiology of disease. 71:234-44
- Chuankhayan, P., Kao, T.T., Lin, C.C., Guan, H.H., Nakagawa, A., Fu, T.F., and Chen, C.J. (2013) Structural Insights into the Hydrolysis and Polymorphism of Methotrexate Polyglutamate by Zebrafish gamma-Glutamyl Hydrolase. Journal of medicinal chemistry. 56(19):7625-7635
- Kao, T.T., Chang, W.N., Wu, H.L., Shi, G.Y., and Fu, T.F. (2009) Recombinant Zebrafish γ-Glutamyl Hydrolase Exhibits Properties and Catalytic Activities Comparable with Those of Mammalian Enzyme. Drug metabolism and disposition: the biological fate of chemicals. 37(2):302-309
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